Document Detail

Asynchronous neuro-osseous growth in adolescent idiopathic scoliosis-MRI-based research.
MedLine Citation:
PMID:  20689947     Owner:  NLM     Status:  In-Data-Review    
Adolescent idiopathic scoliosis (AIS) is a common worldwide problem and has been treated for many decades; however, there still remain uncertain areas about this disorder. Its involvement and impact on different parts of the human body remain underestimated due to lack of technology in imaging for objective assessment in the past. The advances in imaging technique and image analysis technology have provided a novel approach for the understanding of the phenotypic presentation of neuro-osseous changes in AIS patients as compared with normal controls. This review is the summary of morphological assessment of the skeletal and nervous systems in girls with AIS based on MRI. Girls with AIS are found to have morphological differences in multiple areas including the vertebral column, spinal cord, skull and brain when compared with age- and sex-matched normal controls. Taken together, the abnormalities in the skeletal system and nervous system of AIS are likely to be inter-related and reflect a systemic process of asynchronous neuro-osseous growth. The current knowledge about the anatomical changes in AIS has important implications with respect to the understanding of fundamental pathomechanical processes involved in the evolution of the scoliotic deformity.
Winnie C W Chu; Darshana D Rasalkar; Jack C Y Cheng
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Publication Detail:
Type:  Journal Article     Date:  2010-08-06
Journal Detail:
Title:  Pediatric radiology     Volume:  41     ISSN:  1432-1998     ISO Abbreviation:  Pediatr Radiol     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-08-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0365332     Medline TA:  Pediatr Radiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1100-11     Citation Subset:  IM    
Department of Diagnostic Radiology & Organ Imaging, The Chinese University of Hong Kong, Hong Kong, SAR, China,
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