Document Detail


Asynchronous broadband signals are the principal source of the BOLD response in human visual cortex.
MedLine Citation:
PMID:  23770184     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Activity in the living human brain can be studied using multiple methods, spanning a wide range of spatial and temporal resolutions. We investigated the relationship between electric field potentials measured with electrocorticography (ECoG) and the blood oxygen level-dependent (BOLD) response measured with functional magnetic resonance imaging (fMRI). We set out to explain the full set of measurements by modeling the underlying neural circuits.
RESULTS: ECoG responses in visual cortex can be separated into two visually driven components. One component is a specific temporal response that follows each stimulus contrast reversal ("stimulus locked"); the other component is an increase in the response variance ("asynchronous"). For electrodes in visual cortex (V1, V2, V3), the two measures respond to stimuli in the same region of visual space, but they have different spatial summation properties. The stimulus-locked ECoG component sums contrast approximately linearly across space; spatial summation in the asynchronous ECoG component is subadditive. Spatial summation measured using BOLD closely matches the asynchronous component. We created a neural simulation that accurately captures the main features of the ECoG time series; in the simulation, the stimulus-locked and asynchronous components arise from different neural circuits.
CONCLUSIONS: These observations suggest that the two ECoG components arise from different neural sources within the same cortical region. The spatial summation measurements and simulations suggest that the BOLD response arises primarily from neural sources that generate the asynchronous broadband ECoG component.
Authors:
Jonathan Winawer; Kendrick N Kay; Brett L Foster; Andreas M Rauschecker; Josef Parvizi; Brian A Wandell
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-06-13
Journal Detail:
Title:  Current biology : CB     Volume:  23     ISSN:  1879-0445     ISO Abbreviation:  Curr. Biol.     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-07-12     Completed Date:  2014-01-28     Revised Date:  2014-07-13    
Medline Journal Info:
Nlm Unique ID:  9107782     Medline TA:  Curr Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1145-53     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adult
Brain Mapping / methods*
Electroencephalography / methods*
Female
Humans
Magnetic Resonance Imaging / methods*
Male
Middle Aged
Models, Biological
Oxygen / blood*
Visual Cortex / physiology*
Grant Support
ID/Acronym/Agency:
K99 EY022116/EY/NEI NIH HHS; K99-EY022116/EY/NEI NIH HHS; R01 EY003164/EY/NEI NIH HHS; R01 NS078396/NS/NINDS NIH HHS; R01-EY03164/EY/NEI NIH HHS; R01-NS0783961/NS/NINDS NIH HHS; T32 MH020016/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
S88TT14065/Oxygen
Comments/Corrections

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