| Asymptomatic hyperammonemia in patients receiving valproic acid. | |
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MedLine Citation:
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PMID: 6810855 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To determine the frequency of hyperammonemia in asymptomatic patients receiving valproic acid, plasma ammonia concentrations were measured in 55 patients receiving this drug and in 12 patients receiving other anticonvulsants. Twenty-nine of the 55 patients receiving valproic acid and none of the control patients had plasma NH3 levels above the normal range. Ten of the 11 patients receiving both valproic acid and phenytoin sodium in combination had elevated NH3 levels, as did five of six patients receiving both valproic acid and phenobarbital sodium. Elevations in plasma NH3 levels, as high as 140 mumole/L, were well tolerated, and valproic acid dose reductions were not necessary. Based on our findings, hyperammonemia is not an indication for reducing or eliminating valproic acid therapy. |
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Authors:
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J V Murphy; K Marquardt |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives of neurology Volume: 39 ISSN: 0003-9942 ISO Abbreviation: Arch. Neurol. Publication Date: 1982 Sep |
Date Detail:
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Created Date: 1982-10-29 Completed Date: 1982-10-29 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372436 Medline TA: Arch Neurol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 591-2 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Ammonia / blood* Child Child, Preschool Humans Infant Seizures / drug therapy Valproic Acid / adverse effects* |
| Chemical | |
Reg. No./Substance:
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7664-41-7/Ammonia; 99-66-1/Valproic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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