Document Detail

Asymptomatic duodenal ulcers occurring during maintenance treatment with ranitidine.
MedLine Citation:
PMID:  2129644     Owner:  NLM     Status:  MEDLINE    
Fifty-seven patients who developed asymptomatic recurrence of duodenal ulceration during maintenance treatment with ranitidine were followed up to assess the risk of developing symptoms or complications of ulcer disease. The risk of development of symptomatic ulcer recurrence was 4% in the first year of follow-up during continuous maintenance treatment, irrespective of whether or not the asymptomatic ulcer had been actively treated (by doubling the dose of ranitidine used for maintenance therapy). The asymptomatic duodenal ulceration during maintenance treatment did not predispose to complications such as haemorrhage or perforation. It seems, therefore, that patients receiving maintenance treatment for duodenal ulceration do not require endoscopic re-examination unless symptoms have recurred, because the asymptomatic recurrences of duodenal ulceration occurring during maintenance treatment are clinically benign, usually heal spontaneously if maintenance treatment is continued, and do not require active medical intervention.
J G Penston; K G Wormsley
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Alimentary pharmacology & therapeutics     Volume:  4     ISSN:  0269-2813     ISO Abbreviation:  Aliment. Pharmacol. Ther.     Publication Date:  1990 Dec 
Date Detail:
Created Date:  1991-11-05     Completed Date:  1991-11-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8707234     Medline TA:  Aliment Pharmacol Ther     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  569-76     Citation Subset:  IM    
Ninewells Hospital and Medical School, Dundee, UK.
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MeSH Terms
Duodenal Ulcer / diagnosis*,  drug therapy,  epidemiology
Follow-Up Studies
Middle Aged
Ranitidine / therapeutic use*
Risk Factors
Reg. No./Substance:

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