| Asymptomatic duodenal ulcers occurring during maintenance treatment with ranitidine. | |
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MedLine Citation:
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PMID: 2129644 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fifty-seven patients who developed asymptomatic recurrence of duodenal ulceration during maintenance treatment with ranitidine were followed up to assess the risk of developing symptoms or complications of ulcer disease. The risk of development of symptomatic ulcer recurrence was 4% in the first year of follow-up during continuous maintenance treatment, irrespective of whether or not the asymptomatic ulcer had been actively treated (by doubling the dose of ranitidine used for maintenance therapy). The asymptomatic duodenal ulceration during maintenance treatment did not predispose to complications such as haemorrhage or perforation. It seems, therefore, that patients receiving maintenance treatment for duodenal ulceration do not require endoscopic re-examination unless symptoms have recurred, because the asymptomatic recurrences of duodenal ulceration occurring during maintenance treatment are clinically benign, usually heal spontaneously if maintenance treatment is continued, and do not require active medical intervention. |
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Authors:
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J G Penston; K G Wormsley |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Alimentary pharmacology & therapeutics Volume: 4 ISSN: 0269-2813 ISO Abbreviation: Aliment. Pharmacol. Ther. Publication Date: 1990 Dec |
Date Detail:
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Created Date: 1991-11-05 Completed Date: 1991-11-05 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8707234 Medline TA: Aliment Pharmacol Ther Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 569-76 Citation Subset: IM |
Affiliation:
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Ninewells Hospital and Medical School, Dundee, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Child Duodenal Ulcer / diagnosis*, drug therapy, epidemiology Duodenoscopy Female Follow-Up Studies Humans Male Middle Aged Prognosis Ranitidine / therapeutic use* Recurrence Risk Factors |
| Chemical | |
Reg. No./Substance:
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66357-35-5/Ranitidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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