| Asymptomatic cardiovascular manifestations in diabetes mellitus: left ventricular diastolic dysfunction and silent myocardial ischemia. | |
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MedLine Citation:
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PMID: 22069993 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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INTRODUCTION: Several cardiovascular manifestations in patients with diabetes may be asymptomatic. Left ventricular diastolic dysfunction (LVDD) is considered to be the earliest metabolic myocardial lesion in these patients, and can be diagnosed with tissue Doppler echocardiography. Silent myocardial ischemia (SMI) is a characteristic and frequently described form of ischemic heart disease in patients with diabetes. Objective The aim of the study was to assess the prevalence of LVDD and SMI in patients with type 2 diabetes, as well as to compare demographic, clinical, and metabolic data among defined groups (patients with LVDD, patients with SMI and patients with type 2 diabetes, without LVDD and SMI). METHODS: We investigated 104 type 2 diabetic patients (mean age 55.4 +/- 9.1 years, 64.4% males) with normal blood pressure, prehypertension and arterial hypertension stage I. Study design included basic laboratory assessment and cardiological workup (transthoracic echocardiography and tissue Doppler, as well as the exercise stress echocardiography). RESULTS: LVDD was diagnosed in twelve patients (11.5%), while SMI was revealed in six patients (5.8%). Less patients with LVDD were using metformin, in comparison to other two groups (chi2 =12.152; p=0.002). Values of HDL cholesterol (F=4.515; p=0.013) and apolipoprotein A1 (F=5.128; p= 0.008) were significantly higher in patients with LVDD. CONCLUSION: The study confirmed asymptomatic cardiovascular complications in 17.3% patients with type 2 diabetes. |
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Authors:
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Jelena P Seferović-Mitrović; Nebojsa M Lalić; Bosiljka Vujisić-Tesić; Katarina Lalić; Aleksandra Jotić; Arsen D Ristić; Vojislav Giga; Milorad Tesić; Natasa Milić; Ljiljana Lukić; Tanja Milicić; Sandra Singh; Petar M Seferović |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Srpski arhiv za celokupno lekarstvo Volume: 139 ISSN: 0370-8179 ISO Abbreviation: Srp Arh Celok Lek Publication Date: 2011 Sep-Oct |
Date Detail:
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Created Date: 2011-11-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0027440 Medline TA: Srp Arh Celok Lek Country: Serbia |
Other Details:
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Languages: eng Pagination: 599-604 Citation Subset: IM |
Affiliation:
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Department of Endocrinology, Diabetes, and Metabolic Disorders, Clinical Centre of Serbia, Belgrade, Serbia. jpseferovic@yahoo.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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