| Asymptomatic ST-segment depression during exercise testing and the risk of sudden cardiac death in middle-aged men: a population-based follow-up study. | |
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MedLine Citation:
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PMID: 19168533 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: Silent electrocardiographic ST change predicts future coronary events in patients with coronary heart disease (CHD), but the prognostic significance of asymptomatic ST-segment depression with respect to sudden cardiac death in subjects without apparent CHD is not well known. METHODS AND RESULTS: We investigated the association between silent ST-segment depression during and after maximal symptom-limited exercise test and the risk of sudden cardiac death in a population-based sample of 1769 men without evident CHD. A total of 72 sudden cardiac death occurred during the median follow-up of 18 years. The risk of sudden cardiac death was increased among men with asymptomatic ST-segment depression during exercise [hazard ratio (HR) 2.1, 95% confidence interval (CI) 1.2-3.9] as well as among those with asymptomatic ST-segment depression during recovery period (HR 3.2, 95% CI 1.7-6.0). Asymptomatic ST-depression during exercise testing was a stronger predictor for the risk of sudden cardiac death especially among smokers as well as in hypercholesterolaemic and hypertensive men than in men without these risk factors. CONCLUSION: Asymptomatic ST-segment depression was a very strong predictor of sudden cardiac death in men with any conventional risk factor but no previously diagnosed CHD, emphasizing the value of exercise testing to identify asymptomatic high-risk men who could benefit from preventive measures. |
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Authors:
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Jari A Laukkanen; Timo H Mäkikallio; Rainer Rauramaa; Sudhir Kurl |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-01-23 |
Journal Detail:
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Title: European heart journal Volume: 30 ISSN: 1522-9645 ISO Abbreviation: Eur. Heart J. Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-03-02 Completed Date: 2009-04-01 Revised Date: 2013-06-02 |
Medline Journal Info:
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Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: England |
Other Details:
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Languages: eng Pagination: 558-65 Citation Subset: IM |
Affiliation:
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Research Institute of Public Health, University of Kuopio, Kuopio, Finland. jariantero.laukkanen@uku.fi |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Body Mass Index Death, Sudden, Cardiac / epidemiology, etiology* Diabetes Mellitus, Type 2 / complications, epidemiology, physiopathology Electrocardiography Epidemiologic Methods Exercise / physiology* Exercise Test / methods Finland / epidemiology Humans Hypertension / complications, epidemiology Male Middle Aged Prognosis Smoking / adverse effects, epidemiology |
| Grant Support | |
ID/Acronym/Agency:
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HL44199/HL/NHLBI NIH HHS |
| Comments/Corrections | |
Comment In:
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Eur Heart J. 2009 Mar;30(5):528-9
[PMID:
19201762
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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