| Asymptomatic colonization by Clostridium difficile in infants: implications for disease in later life. | |
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MedLine Citation:
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PMID: 20512057 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Approximately 60% to 70% of healthy newborns and infants are colonized by the enteric pathogen Clostridium difficile. For reasons that remain obscure, these colonized infants show no ill effects from the potent exotoxins released by this anaerobe, in contrast to older children and adults who are susceptible to severe diarrhea and colitis. The organism is acquired in infancy, as in adults, from environmental contamination in the nursery or home environment. Between 12 and 24 months C difficile is evicted as a commensal, presumably by the gradual development of the adult colonic microflora. The carrier state is well tolerated by infants, and the immunoglobulin G antitoxin response that develops during the carrier state appears to provide durable protection against subsequent C difficile disease. |
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Authors:
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Sushrut Jangi; J Thomas Lamont |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of pediatric gastroenterology and nutrition Volume: 51 ISSN: 1536-4801 ISO Abbreviation: J. Pediatr. Gastroenterol. Nutr. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-28 Completed Date: 2011-01-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8211545 Medline TA: J Pediatr Gastroenterol Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 2-7 Citation Subset: IM |
Affiliation:
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Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptive Immunity* Carrier State* Clostridium difficile* / growth & development, isolation & purification Colon / microbiology* Colony Count, Microbial Exotoxins Humans Immunoglobulin G Infant Infant, Newborn* |
| Chemical | |
Reg. No./Substance:
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0/Exotoxins; 0/Immunoglobulin G |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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