Document Detail


Asymmetry: molecular, biologic, embryopathic, and clinical perspectives.
MedLine Citation:
PMID:  11471152     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This overview of asymmetry addresses the following topics: chiral molecules; asymmetric signaling molecules, including N-cadherin, Shh, Fgf8, lefty1, lefty2, nodal, Pitx2, activin betaB, activin receptor IIA, and cSnR; situs abnormalities; asymmetric cell division; laterality in humans and animals; behavioral asymmetry in humans and animals; asymmetric embryopathies, including Tessier-type "clefts"; hemiasymmetries such as hemihyperplasia, hemihypoplasia, and hemiatrophy; asymmetric vascular syndromes, including Klippel-Trenaunay and Sturge-Weber syndromes; plagiocephaly of the synostotic and deformational types; somatic mosaicism, including a discussion of McCune-Albright syndrome, fibrous dysplasia, GNAS1 mutations, and Proteus syndrome.
Authors:
M M Cohen
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  American journal of medical genetics     Volume:  101     ISSN:  0148-7299     ISO Abbreviation:  Am. J. Med. Genet.     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-07-25     Completed Date:  2001-08-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7708900     Medline TA:  Am J Med Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  292-314     Citation Subset:  IM    
Copyright Information:
Copyright 2001 Wiley-Liss, Inc.
Affiliation:
Department of Oral & Maxillofacial Pathology, Dalhousie University, Halifax, Nova Scotia, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Patterning / genetics
Cell Division / genetics
Congenital Abnormalities / embryology,  genetics*,  pathology
Eye Abnormalities / embryology,  genetics,  pathology
Gene Expression Regulation
Humans

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