Document Detail


Asymmetry of lower esophageal sphincter pressure: is it related to the muscle thickness or its shape?
MedLine Citation:
PMID:  9227488     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lower esophageal sphincter (LES) pressure shows axial and circumferential asymmetry, the reasons for which are not clear. Our aim was to determine whether the muscle thickness and shape of the LES were the reasons for the axial and circumferential asymmetry in the LES pressure. High-frequency, catheter-based intraluminal ultrasonography was performed to obtain images of the human LES and esophagus. Station pull-through manometry was performed to record the axial and circumferential asymmetry of LES pressure. Circular and longitudinal muscle were thicker in the LES compared with in the esophagus. There was a close correlation between the axial asymmetry in LES pressure and circular muscle thickness. The thickness of LES muscle increased and decreased with an increase and decrease in the LES pressure, respectively. The circumferential asymmetry in resting LES pressure was related to the noncircular shape of the LES. A swallow-induced LES relaxation was followed by its contraction. During the contraction phase, the LES and esophagus showed relative symmetry in pressure and shape. We conclude that the axial asymmetry of LES pressure is explained by its muscle thickness. On the other hand, circumferential asymmetry is related to the noncircular shape of the LES.
Authors:
J Liu; V K Parashar; R K Mittal
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  272     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1997 Jun 
Date Detail:
Created Date:  1997-08-18     Completed Date:  1997-08-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  G1509-17     Citation Subset:  IM    
Affiliation:
Division of Gastroenterology and Hepatology, University of Virginia, Charlottesville 22906, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Esophagogastric Junction / anatomy & histology,  physiology*,  ultrasonography
Female
Humans
Male
Manometry / methods
Muscle, Smooth / anatomy & histology,  physiology*,  ultrasonography
Pressure
Stomach / anatomy & histology,  physiology,  ultrasonography
Grant Support
ID/Acronym/Agency:
R29-DK-45027/DK/NIDDK NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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