Document Detail


Asymmetrical ventricular enlargement in Parkinson's disease.
MedLine Citation:
PMID:  17588238     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Parkinson's disease (PD) typically manifests with asymmetric motor symptom onset. Ventricular enlargement, a nonspecific measure of brain atrophy, has been associated with cognitive decline in PD, but not with motor symptom asymmetry. Asymmetrical ventricular enlargement on magnetic resonance images was explored in a monozygotic twin pair discordant for PD and in nine healthy monozygotic twin pairs. The left-right lateral ventricular volumetric difference of the PD-twin was greater than that of his twin and all other healthy twins, with the larger ventricle observed contralateral to the more symptomatic side. Moreover, the lateral ventricle asymmetry difference between twin pairs was significantly higher for the discordant PD-twin pair than for the healthy twin pairs. This is the first report to suggest the presence of asymmetrical ventricular enlargement in PD, findings that may be worthy of further study.
Authors:
Xuemei Huang; Yueh Z Lee; Martin McKeown; Guido Gerig; Hongbin Gu; Weili Lin; Mechelle M Lewis; Sutapa Ford; Alexander I Tröster; Daniel R Weinberger; Martin Styner
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Movement disorders : official journal of the Movement Disorder Society     Volume:  22     ISSN:  0885-3185     ISO Abbreviation:  Mov. Disord.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-09-05     Completed Date:  2007-11-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8610688     Medline TA:  Mov Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1657-60     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2007 Movement Disorder Society.
Affiliation:
Department of Neurology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599-7025, USA, and University Hospital, Vancouver, British Columbia, Canada. xuemei@med.unc.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Cerebral Ventricles / pathology*
Diseases in Twins*
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Parkinson Disease / pathology*
Twin Studies as Topic
Grant Support
ID/Acronym/Agency:
AG21491/AG/NIA NIH HHS; RR00046/RR/NCRR NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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