| Asymmetrical ventricular enlargement in Parkinson's disease. | |
| | |
MedLine Citation:
|
PMID: 17588238 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Parkinson's disease (PD) typically manifests with asymmetric motor symptom onset. Ventricular enlargement, a nonspecific measure of brain atrophy, has been associated with cognitive decline in PD, but not with motor symptom asymmetry. Asymmetrical ventricular enlargement on magnetic resonance images was explored in a monozygotic twin pair discordant for PD and in nine healthy monozygotic twin pairs. The left-right lateral ventricular volumetric difference of the PD-twin was greater than that of his twin and all other healthy twins, with the larger ventricle observed contralateral to the more symptomatic side. Moreover, the lateral ventricle asymmetry difference between twin pairs was significantly higher for the discordant PD-twin pair than for the healthy twin pairs. This is the first report to suggest the presence of asymmetrical ventricular enlargement in PD, findings that may be worthy of further study. |
| | |
Authors:
|
Xuemei Huang; Yueh Z Lee; Martin McKeown; Guido Gerig; Hongbin Gu; Weili Lin; Mechelle M Lewis; Sutapa Ford; Alexander I Tröster; Daniel R Weinberger; Martin Styner |
Related Documents
:
|
7728518 - Diverging asymmetries of temporo-parietal cortical areas: a reappraisal of geschwind/ga... 2729348 - Acrocallosal syndrome in a girl born to consanguineous parents. 6982218 - An excess of the pi s allele in dizygotic twins and their mothers. 8771488 - Maintaining the safe position in a palmar splint. the "double-t" plaster splint. 9571338 - The effect of glycemic control in the pre-conception period and early pregnancy on birt... 22522148 - Terminating pregnancy after prenatal diagnosis--with a little help of professional ethics? |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
|
Title: Movement disorders : official journal of the Movement Disorder Society Volume: 22 ISSN: 0885-3185 ISO Abbreviation: Mov. Disord. Publication Date: 2007 Aug |
Date Detail:
|
Created Date: 2007-09-05 Completed Date: 2007-11-28 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8610688 Medline TA: Mov Disord Country: United States |
Other Details:
|
Languages: eng Pagination: 1657-60 Citation Subset: IM |
Copyright Information:
|
Copyright (c) 2007 Movement Disorder Society. |
Affiliation:
|
Department of Neurology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599-7025, USA, and University Hospital, Vancouver, British Columbia, Canada. xuemei@med.unc.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Cerebral Ventricles / pathology* Diseases in Twins* Female Humans Magnetic Resonance Imaging Male Middle Aged Parkinson Disease / pathology* Twin Studies as Topic |
| Grant Support | |
ID/Acronym/Agency:
|
AG21491/AG/NIA NIH HHS; RR00046/RR/NCRR NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Validation of a swallowing disturbance questionnaire for detecting dysphagia in patients with Parkin...
Next Document: A progressive, fatal dystonia-Parkinsonism syndrome in a patient with primary immunodeficiency recei...