Document Detail


Asymmetrical septal hypertrophy in patients with hypertension: a type of hypertensive left ventricular hypertrophy or hypertrophic cardiomyopathy combined with hypertension?
MedLine Citation:
PMID:  8416759     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To determine whether asymmetrical septal hypertrophy (ASH) in patients with essential hypertension (HT) is a type of hypertensive left ventricular (LV) hypertrophy or hypertrophic cardiomyopathy (HCM) combined with HT, we investigated a group of 7 hypertensive patients with ASH compared with 12 HCM patients and 10 healthy controls using radionuclide angiography and right ventricular endomyocardial biopsy. The LV time-volume curve and its first and second derivative curves were constructed from cardiac output and time-activity curves constructed by combined forward and reverse-gating from the R wave. The LV wall thickness and ejection fraction were significantly greater in both the HT and HCM groups than in the control group, whereas there were no differences in these indices between the HT and HCM groups. Rapid filling volume index and rapid filling fraction showed significantly lower values in the HCM group than in the control group (p < 0.005). In contrast to the HCM group, these indices in the HT group did not differ from those in the control group. The time to peak filling rate was prolonged in the control, hypertension, and HCM groups in increasing order. Histopathological study revealed a higher incidence of myocardial cell disarray in the HCM than in the HT group. The above results suggest that ASH in hypertensive patients is a type of hypertensive LV hypertrophy.
Authors:
M Shimizu; N Sugihara; K Shimizu; H Yoshio; H Ino; K Nakajima; R Takeda
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical cardiology     Volume:  16     ISSN:  0160-9289     ISO Abbreviation:  Clin Cardiol     Publication Date:  1993 Jan 
Date Detail:
Created Date:  1993-01-28     Completed Date:  1993-01-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7903272     Medline TA:  Clin Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  41-6     Citation Subset:  IM    
Affiliation:
Second Department of Internal Medicine, Kanazawa University, Japan.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Biopsy
Cardiomyopathy, Hypertrophic / complications*,  pathology,  physiopathology
Echocardiography
Female
Gated Blood-Pool Imaging
Heart Function Tests*
Hemodynamics
Humans
Hypertension / complications*,  physiopathology
Male
Middle Aged
Myocardium / pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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