Document Detail


Asymmetrical effects of albumin on transsynovial fluid movement.
MedLine Citation:
PMID:  1788556     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of intraarticular infusions of albumin solution on transsynovial flow was studied in healthy rabbit knee joints and compared with the effect of albumin solution perfused through the synovial microcirculation. Increasing intravascular albumin levels enhanced fluid absorption from the joint cavity, whereas increasing intraarticular albumin levels reduced the absorption rate. The slope of intraarticular pressure-versus-absorption rate plots was reduced by albumin in proportion to the reduction in fluidity (1/viscosity). When joint pressure was held constant, the transsynovial absorption rate was reduced by albumin in excess of the fluidity reduction and even reversed to filtration into the joint cavity. Thus intraarticular albumin acts by a dual mechanism, namely by increasing synovial interstitial fluid viscosity and by exerting a peri-capillary oncotic pressure. However, the latter effect was much less than that of intravascular albumin. Reasons for this are discussed.
Authors:
J R Levick; J N McDonald; A D Knight
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Seminars in arthritis and rheumatism     Volume:  21     ISSN:  0049-0172     ISO Abbreviation:  Semin. Arthritis Rheum.     Publication Date:  1991 Dec 
Date Detail:
Created Date:  1992-03-24     Completed Date:  1992-03-24     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  1306053     Medline TA:  Semin Arthritis Rheum     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  184-90     Citation Subset:  IM    
Affiliation:
Department of Physiology, St George's Hospital Medical School, London, England.
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MeSH Terms
Descriptor/Qualifier:
Absorption
Animals
Colloids / pharmacokinetics
Infusion Pumps
Injections, Intra-Articular
Knee Joint / metabolism,  physiology
Osmolar Concentration
Osmotic Pressure
Pressure
Rabbits
Serum Albumin / pharmacology,  physiology*
Synovial Fluid / metabolism*
Chemical
Reg. No./Substance:
0/Colloids; 0/Serum Albumin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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