Document Detail


Asymmetric vascular stent: feasibility study of a new low-porosity patch-containing stent.
MedLine Citation:
PMID:  18436886     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: Intracranial aneurysm (IA) treatment through hemodynamic modification with novel stent designs is a burgeoning area of research. We present a feasibility study for a new low-porosity patch-containing stent designed to treat intracranial aneurysms. The device is deployed so the patch covers the aneurysm neck ensuring strong flow diversion away from the aneurysm while keeping a low probability of occlusion of perforating vessels.
METHODS: We created 17 side-wall aneurysms in 6 dogs, 2 per carotid artery if animal size permitted. Twelve proximal aneurysms were treated with AVSs: 5 distal aneurysms were untreated, serving as controls against self-thrombosis; 7 treated aneurysms were fully-covered; and 5 were partially-covered. After 4 weeks, a final angiogram was performed and aneurysms were explanted. Angiograms acquired pre- and posttreatment and at 4-week follow-up were analyzed quantitatively using normalized time-density curves (NTDC). Cone-beam micro-CT and histological specimen analysis were then performed.
RESULTS: Posttreatment, NTDC average peaks dropped to 45% of initial values for the partially-covered aneurysms and 78% for the fully-covered aneurysms. Cone-beam micro-CT imaging performed at 4 weeks posttreatment showed partial thrombosis in 4 of 5 partially-covered aneurysms and complete thrombosis in all fully-covered aneurysms. Histology revealed neointimal coverage of all asymmetrical patch regions and thrombus formation in both fully- and partially-covered aneurysms. Four-week follow-up was not done for 1 animal (2 controls, 2 treated) that expired because of groin hemorrhage and for another animal (1 aneurysm) with an occluded carotid.
CONCLUSIONS: We demonstrate aneurysmal blood flow diversion using a new low-porosity patch-containing asymmetrical vascular stent in a canine side-wall aneurysm model. Overall results are encouraging and support continued AVS development.
Authors:
Ciprian N Ionita; Ann M Paciorek; Kenneth R Hoffmann; Daniel R Bednarek; Junichi Yamamoto; John Kolega; Elad I Levy; L Nelson Hopkins; Stephen Rudin; J Mocco
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2008-04-24
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  39     ISSN:  1524-4628     ISO Abbreviation:  Stroke     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-24     Completed Date:  2008-07-23     Revised Date:  2014-09-20    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2105-13     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Angiography
Animals
Blood Vessel Prosthesis*
Carotid Arteries / pathology
Cohort Studies
Cone-Beam Computed Tomography / methods
Dogs
Equipment Design
Feasibility Studies
Hemodynamics
Intracranial Aneurysm*
Porosity
Probability
Stents*
Tomography, X-Ray Computed
Grant Support
ID/Acronym/Agency:
R01 EB002873/EB/NIBIB NIH HHS; R01 EB002873-05/EB/NIBIB NIH HHS; R01 NS043924/NS/NINDS NIH HHS; R01 NS043924-04/NS/NINDS NIH HHS; R01EB002873/EB/NIBIB NIH HHS; R01NS43924/NS/NINDS NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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