Document Detail


Asymmetric transfer hydrogenation of beta,gamma-alkynyl alpha-imino esters by a Brønsted acid.
MedLine Citation:
PMID:  18422288     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Asymmetric synthesis of trans-alkenyl alpha-amino esters was realized by chiral phosphoric acid catalyzed transfer hydrogenation of beta,gamma-alkynyl alpha-imino esters. Utilizing Hantzsch esters as the hydrogen donor, both the alkyne and imine moieties of beta,gamma-alkynyl alpha-imino esters were reduced to afford trans-alkenyl alpha-amino esters with up to 96% ee.
Authors:
Qiang Kang; Zhuo-An Zhao; Shu-Li You
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-04-18
Journal Detail:
Title:  Organic letters     Volume:  10     ISSN:  1523-7060     ISO Abbreviation:  Org. Lett.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-09     Completed Date:  2008-07-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100890393     Medline TA:  Org Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2031-4     Citation Subset:  IM    
Affiliation:
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China.
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MeSH Terms
Descriptor/Qualifier:
Catalysis
Esters / chemical synthesis*,  chemistry
Hydrogenation
Imino Acids / chemical synthesis*,  chemistry
Molecular Structure
Oxidation-Reduction
Phosphoric Acids / chemistry*
Chemical
Reg. No./Substance:
0/Esters; 0/Imino Acids; 0/Phosphoric Acids; 7664-38-2/phosphoric acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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