Document Detail


Asymmetric stem cell division: lessons from Drosophila.
MedLine Citation:
PMID:  18328747     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Asymmetric cell division is an important and conserved strategy in the generation of cellular diversity during animal development. Many of our insights into the underlying mechanisms of asymmetric cell division have been gained from Drosophila, including the establishment of polarity, orientation of mitotic spindles and segregation of cell fate determinants. Recent studies are also beginning to reveal the connection between the misregulation of asymmetric cell division and cancer. What we are learning from Drosophila as a model system has implication both for stem cell biology and also cancer research.
Authors:
Pao-Shu Wu; Boris Egger; Andrea H Brand
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-02-02
Journal Detail:
Title:  Seminars in cell & developmental biology     Volume:  19     ISSN:  1084-9521     ISO Abbreviation:  Semin. Cell Dev. Biol.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-04-08     Completed Date:  2008-09-19     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  9607332     Medline TA:  Semin Cell Dev Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  283-93     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Division*
Cell Lineage
Drosophila melanogaster / cytology*
Neoplasms / pathology
Spindle Apparatus / metabolism
Stem Cells / cytology*
Grant Support
ID/Acronym/Agency:
068055//Wellcome Trust; G0300072//Medical Research Council; //Wellcome Trust

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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