Document Detail


Asymmetric septal hypertrophy and myocardial fiber disarray. Features of normal, developing, and malformed hearts.
MedLine Citation:
PMID:  141348     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The specificity and significance of the asymmetric septal hypertrophy (ASH) and myocardial fiber disarray of idiopathic hypertrophic subaortic stenosis (IHSS) is uncertain. To examine this we studied 215 hearts, including normal embryos, fetuses, children, and adults; and hearts with congenital and acquired disease. Disproportionate septal thickening was present in all embryos and in some abnormal hearts, particularly those with severe right ventricular hypertrophy due to congenital malformations. Some myocardial fiber disarray was present in all hearts at the junctions of interventricular septum and ventricular free wall. In hearts with semilunar valve atresia with intact ventricular septums, and in the infundibulum of some with tetralogy of Fallot, however, extensive fiber disarray was present. Thus, ASH occurs in the normal developing heart and in some malformed hearts with RVH; marked muscle fiber disarray may occur in certain congenital lesions with abnormal systolic contraction. Neither morphologic finding independently or in combination is pathognomonic of idiopathic hypertrophic subaortic stenosis.
Authors:
B H Bulkley; M L Weisfeldt; G M Hutchins
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation     Volume:  56     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1977 Aug 
Date Detail:
Created Date:  1977-09-02     Completed Date:  1977-09-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  292-8     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Cardiomegaly / pathology*
Child
Fetal Heart / pathology*
Heart / anatomy & histology
Heart Defects, Congenital / pathology*
Heart Septal Defects, Ventricular / pathology
Heart Septum / anatomy & histology,  embryology,  pathology*
Humans
Infant, Newborn
Myocardium / pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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