| Asymmetric septal hypertrophy in infants of diabetic mothers. Fetal echocardiography and the impact of maternal diabetic control. | |
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MedLine Citation:
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PMID: 1733154 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Maternal hyperglycemia may result in fetal hyperinsulinemia and asymmetric septal hypertrophy, macrosomia, and hypoglycemia in infants of diabetic mothers. We monitored glycosylated hemoglobin levels in 61 pregnant diabetic women each trimester as an index of maternal glycemic control and did serial fetal echocardiograms starting at 18 weeks of gestation. At delivery, cord blood C-peptide levels were obtained as an index of fetal hyperinsulinemia. Infants were assessed for hypoglycemia, macrosomia and septal thickening by echocardiography. Nineteen of the 61 infants (31%) had septal hypertrophy, were heavier, and had higher cord blood C-peptide levels and lower serum glucose levels than unaffected infants. Maternal glycosylated hemoglobin levels were higher during the third trimester in mothers of affected infants. Our data support a possible relationship between third-trimester maternal hyperglycemia and neonatal asymmetric septal hypertrophy, macrosomia, and hypoglycemia. |
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Authors:
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M J Cooper; M A Enderlein; H Tarnoff; C L Rogé |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of diseases of children (1960) Volume: 146 ISSN: 0002-922X ISO Abbreviation: Am. J. Dis. Child. Publication Date: 1992 Feb |
Date Detail:
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Created Date: 1992-02-25 Completed Date: 1992-02-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370471 Medline TA: Am J Dis Child Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 226-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics, Kaiser Permanente Medical Centers, CA 94589. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Echocardiography Female Gestational Age Heart Septum / embryology*, ultrasonography* Hemoglobin A, Glycosylated / metabolism Humans Hypertrophy / embryology, ultrasonography Infant, Newborn Pregnancy Pregnancy in Diabetics / blood, complications* Ultrasonography, Prenatal |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobin A, Glycosylated |
| Comments/Corrections | |
Comment In:
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Am J Dis Child. 1992 Sep;146(9):1021-2
[PMID:
1514543
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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