Document Detail


Asymmetric reduction of (S)-3-chloro-1-phenylpropanol from 3-chloropropiophenone by preheated immobilized Candida utilis.
MedLine Citation:
PMID:  19633816     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An efficient method for asymmetric reduction of (S)-3-chloro-1-phenylpropanol from 3-chloropropiophenone was developed using preheated Candida utilis cells immobilized in calcium alginate gel beads. Heating the immobilized cells (bead diameter 1.5 mm) at 45 degrees C for 50 min allowed the reaction to proceed with 99.5% enantiomeric excess (ee) and an 85% yield with 1 g substrate l(-1) (batch addition in three aliquots) in 48 h. The immobilized cells retained approximately 50% of their original catalytic activity after being reused three times.
Authors:
Yang Gen-Sheng; Xu Jiang-Yan; Ou Zhi-Min; Yao Shan-Jing
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-07-25
Journal Detail:
Title:  Biotechnology letters     Volume:  31     ISSN:  1573-6776     ISO Abbreviation:  Biotechnol. Lett.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-05     Completed Date:  2010-01-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8008051     Medline TA:  Biotechnol Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1879-83     Citation Subset:  IM    
Affiliation:
College of Pharmaceutical Science, Zhejiang University of Technology, 310032, Hangzhou, People's Republic of China. yanggs@zjut.edu.cn
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MeSH Terms
Descriptor/Qualifier:
Alginates / chemistry
Candida / metabolism*
Cells, Immobilized
Glucuronic Acid / chemistry
Heating
Hexuronic Acids / chemistry
Hydrocarbons, Chlorinated / metabolism*
Oxidation-Reduction
Propanols / metabolism*
Propiophenones / metabolism*
Temperature
Time Factors
Chemical
Reg. No./Substance:
0/3-chloro-1-phenylpropanol; 0/Alginates; 0/Hexuronic Acids; 0/Hydrocarbons, Chlorinated; 0/Propanols; 0/Propiophenones; 576-37-4/Glucuronic Acid; 9005-32-7/alginic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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