| Asymmetric reduction of (S)-3-chloro-1-phenylpropanol from 3-chloropropiophenone by preheated immobilized Candida utilis. | |
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MedLine Citation:
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PMID: 19633816 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An efficient method for asymmetric reduction of (S)-3-chloro-1-phenylpropanol from 3-chloropropiophenone was developed using preheated Candida utilis cells immobilized in calcium alginate gel beads. Heating the immobilized cells (bead diameter 1.5 mm) at 45 degrees C for 50 min allowed the reaction to proceed with 99.5% enantiomeric excess (ee) and an 85% yield with 1 g substrate l(-1) (batch addition in three aliquots) in 48 h. The immobilized cells retained approximately 50% of their original catalytic activity after being reused three times. |
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Authors:
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Yang Gen-Sheng; Xu Jiang-Yan; Ou Zhi-Min; Yao Shan-Jing |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-07-25 |
Journal Detail:
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Title: Biotechnology letters Volume: 31 ISSN: 1573-6776 ISO Abbreviation: Biotechnol. Lett. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-05 Completed Date: 2010-01-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8008051 Medline TA: Biotechnol Lett Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1879-83 Citation Subset: IM |
Affiliation:
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College of Pharmaceutical Science, Zhejiang University of Technology, 310032, Hangzhou, People's Republic of China. yanggs@zjut.edu.cn |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alginates
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chemistry Candida / metabolism* Cells, Immobilized Glucuronic Acid / chemistry Heating Hexuronic Acids / chemistry Hydrocarbons, Chlorinated / metabolism* Oxidation-Reduction Propanols / metabolism* Propiophenones / metabolism* Temperature Time Factors |
| Chemical | |
Reg. No./Substance:
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0/3-chloro-1-phenylpropanol; 0/Alginates; 0/Hexuronic Acids; 0/Hydrocarbons, Chlorinated; 0/Propanols; 0/Propiophenones; 576-37-4/Glucuronic Acid; 9005-32-7/alginic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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