| Asymmetric poly(ethylene glycol) star polymers with a cholic acid core and their aggregation properties. | |
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MedLine Citation:
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PMID: 19281151 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Poly(ethylene glycol) (PEG) arms are grafted onto a cholic acid core via anionic polymerization, yielding star-shaped polymers with a unique asymmetric structure with facial amphiphilicity. Well-defined cholic acid-PEG(4) stars (polydispersity index, ca. 1.05) with tunable molar masses (ca. 1000-13,000) were obtained and characterized by the use of size exclusion chromatography, MALDI-TOF mass spectrometry, NMR spectroscopy, and thermal analysis. The asymmetric star polymers were found to aggregate differently from cholic acid salt. The critical aggregation concentrations of the star polymers were determined by surface tension measurements, and spherical aggregates of the polymers with different PEG chain lengths were observed by transmission electron microscopy using the freeze-fracture etching technique. The elongated aggregates formed by the sodium salt of cholic acid were also observed. The hydrodynamic diameters of the aggregates were also measured using dynamic light scattering technique. The formation of aggregates makes them interesting systems as potential drug carriers. |
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Authors:
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Juntao Luo; Guillaume Gigu??re; X X Zhu |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biomacromolecules Volume: 10 ISSN: 1526-4602 ISO Abbreviation: Biomacromolecules Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-04-13 Completed Date: 2010-02-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100892849 Medline TA: Biomacromolecules Country: United States |
Other Details:
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Languages: eng Pagination: 900-6 Citation Subset: IM |
Affiliation:
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D??partement de Chimie, Universit?? de Montr??al, C.P. 6128, Succursale Centre-ville, Montr??al, QC, Canada H3C 3J7. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cholic Acid
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chemistry* Chromatography, Gel Magnetic Resonance Spectroscopy Microscopy, Electron, Transmission Polyethylene Glycols / chemistry* Polymers / chemical synthesis, chemistry*, metabolism* Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Spectroscopy, Fourier Transform Infrared |
| Chemical | |
Reg. No./Substance:
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0/Polyethylene Glycols; 0/Polymers; 81-25-4/Cholic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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