Document Detail


Asymmetric metabolism of hypothalamic catecholamines alternates with side of ovulation in a lizard (Anolis carolinensis).
MedLine Citation:
PMID:  1583449     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We determined levels of monoamines and their metabolites in 2 hypothalami dissected from the right and left hemibrains of 15 females during the right-left alternating ovulatory cycle of Anolis carolinensis. Tissue contents of the following were measured using HPLC and electrochemical (coulometric) detection: dopamine (DA) and its metabolite 2,4-dihydroxyphenylacetic acid (DOPAC), norepinephrine (NE) and its metabolites 3-methoxy-4-hydroxyphenylglycol (MHPG) and 3,4-dihydroxyphenylglycol (DHPG), and serotonin (5-HT) and its metabolite 5-hydroxyindoleacetic acid (5-HIAA). An asymmetry ratio (AR) was determined by subtracting hypothalamic content (pM/mg) on the larger ovary (LO) side from that on the smaller ovary (SO) side, divided by the sum of the 2 sides (AR = SO - LO/SO+LO). The Ar of MHPG and DHPG both decreased as the largest follicle in the LO grew during the cycle, from greater than 0 (content higher on the SO side) at the beginning of the cycle to less than 0 (content higher on the LO side). The average content of MHPG in the 2 sides significantly increased during the cycle. There were no significant asymmetric changes in hypothalamic DA or DOPAC. The average content of DA increased during the cycle, whereas the content of DOPAC, as well as DOPAC/DA, did not change. The average content of 5-HT increased, and the average metabolite ratio of 5-HIAA/5-HT decreased during the cycle without significant asymmetries. The metabolite ratios of NE and DA, but not 5-HT, were asymmetric on the same side in a given female.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
P H Desan; K H Lopez; H B Austin; R E Jones
Related Documents :
2078309 - Amino acid concentrations in cerebrospinal fluid and plasma in alzheimer's disease and ...
1690639 - Quinolinic acid concentrations in brain and cerebrospinal fluid of patients with intrac...
9757559 - Purification and characterization of recombinant human granulocyte colony-stimulating f...
6391739 - Stable isotope dilution analysis of orotic acid and uracil in amniotic fluid.
7710669 - Cerebrospinal monoamine metabolites and amino acid content in patients with parkinsonia...
1409779 - Bilateral neurochemical changes induced by unilateral cerebral haloperidol administrati...
9801199 - Use of a broad-host-range bacteriocin-producing lactococcus lactis transconjugant as an...
22126349 - Remineralization and acid resistance of enamel lesions after chewing gum containing flu...
23108959 - Uvb radiation variably affects n-3 fatty acids but elevated temperature reduces n-3 fat...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of experimental zoology     Volume:  262     ISSN:  0022-104X     ISO Abbreviation:  J. Exp. Zool.     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-06-16     Completed Date:  1992-06-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375365     Medline TA:  J Exp Zool     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  105-12     Citation Subset:  IM    
Affiliation:
Department of Environmental, Population and Organismic Biology, University of Colorado, Boulder 80309.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Biogenic Monoamines / metabolism
Catecholamines / metabolism*
Dopamine / metabolism
Female
Hypothalamus / metabolism*
Lizards
Norepinephrine / metabolism
Ovary / metabolism
Ovulation / physiology*
Regression Analysis
Serotonin / metabolism
Grant Support
ID/Acronym/Agency:
1-R01-HD27122-01A1/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Biogenic Monoamines; 0/Catecholamines; 50-67-9/Serotonin; 51-41-2/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Characterization of leukotriene C4 binding sites in the brain of the American bullfrog, Rana catesbe...
Next Document:  Intra- and extra-cellular sources of T3 binding to putative thyroid hormone receptors in liver, kidn...