| Asymmetric dimethylarginine: clinical applications in pediatric medicine. | |
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MedLine Citation:
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PMID: 21377060 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase (NOS). Growing evidence indicates that ADMA plays an important role in the initiation and progression of a variety of adulthood diseases, especially in the cardiovascular and renal systems. However, the study of ADMA in pediatric diseases has just begun. This review provides an overview of potential clinical applications of ADMA in pediatric practice, with an emphasis on the following areas: the biochemistry and pathophysiology of ADMA; clinical ramifications of elevated ADMA levels in pediatric population; age-related normal reference ranges of ADMA; methodology for measuring ADMA; current and potential agents to reduce ADMA; and the problems that must be addressed before use of ADMA in pediatric medicine. ADMA will soon be available for use as a biomarker and therapeutic target in the pediatric population. |
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Authors:
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You-Lin Tain; Li-Tung Huang |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the Formosan Medical Association = Taiwan yi zhi Volume: 110 ISSN: 0929-6646 ISO Abbreviation: J. Formos. Med. Assoc. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-03-07 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9214933 Medline TA: J Formos Med Assoc Country: China (Republic : 1949- ) |
Other Details:
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Languages: eng Pagination: 70-7 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Formosan Medical Association & Elsevier. Published by Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Pediatrics, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University, College of Medicine, Taiwan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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