Document Detail


Asymmetric dimethylarginine (ADMA): a novel risk marker in cardiovascular medicine and beyond.
MedLine Citation:
PMID:  16581698     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There is abundant evidence that the endothelium plays a crucial role in the maintenance of vascular tone and structure. One of the major endothelium-derived vasoactive mediators is nitric oxide (NO), an endogenous messenger molecule formed in healthy vascular endothelium from the amino acid precursor L-arginine. Endothelial dysfunction is caused by various cardiovascular risk factors, metabolic diseases, and systemic or local inflammation. One mechanism that explains the occurrence of endothelial dysfunction is the presence of elevated blood levels of asymmetric dimethylarginine (ADMA)--an L-arginine analogue that inhibits NO formation and thereby can impair vascular function. Supplementation with L-arginine has been shown to restore vascular function and to improve the clinical symptoms of various diseases associated with vascular dysfunction.
Authors:
Rainer H Böger
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annals of medicine     Volume:  38     ISSN:  0785-3890     ISO Abbreviation:  Ann. Med.     Publication Date:  2006  
Date Detail:
Created Date:  2006-04-03     Completed Date:  2006-08-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8906388     Medline TA:  Ann Med     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  126-36     Citation Subset:  IM    
Affiliation:
Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Hospital Hamburg-Eppendorf, Hamburg, Germany. boeger@uke.uni-hamburg.de
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MeSH Terms
Descriptor/Qualifier:
Arginine / analogs & derivatives*,  blood,  metabolism,  urine
Arteriosclerosis / blood,  diagnosis*
Biological Markers / blood
Cardiovascular Diseases / blood,  diagnosis*,  metabolism
Clinical Trials as Topic
Endothelium, Vascular / metabolism
Female
Humans
Hyperthyroidism / blood
Insulin Resistance
Liver Failure / blood
Male
Metabolic Syndrome X / blood
Nitric Oxide / metabolism
Nitric Oxide Synthase / antagonists & inhibitors*
Pre-Eclampsia / blood
Pregnancy
Risk Factors
Stereoisomerism
Chemical
Reg. No./Substance:
0/Biological Markers; 10102-43-9/Nitric Oxide; 30344-00-4/N,N'-dimethylarginine; 74-79-3/Arginine; EC 1.14.13.39/Nitric Oxide Synthase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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