Document Detail


Asymmetric (differential) cell division of thymic lymphocytes by means of cytoplasmic polarization: possible biological meanings.
MedLine Citation:
PMID:  6606874     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A series of morphological studies at the light- and electron-microscopical levels have led to the conclusion that a significant proportion of immature thymic lymphocytes would undergo asymmetric (differential) cell division: at the telophase of such dividing cells one of two daughter cells retains morphological characteristics very similar to those of its parent cell, whereas the counterpart daughter cell looks much differentiated. Polarization of the cytoplasm is considered to be the mechanism whereby the asymmetry is generated. The phenomenon is observable in both prenatal and postnatal life of all the animal species examined, that is chicken, guinea pig, rat and mouse, meaning that it is a general phenomenon among the animals possessing the thymus. The frequency of asymmetrically-dividing cells is relatively high in large-sized cell fractions (more than 40% of total dividing cells). The conclusions leading from the above-mentioned morphological studies are supported by the cell kinetic studies performed by Metcalf in the mid-1960s. Asymmetric cell division may be primarily involved in the maintenance of immature 'stem cells' while concomitantly producing differentiated cells of smaller sizes. The phenomenon might also play an important role in the differentiation of thymocytes into distinct lineage of thymic lymphocytes such as cortex and medulla lymphocytes. Furthermore, the present findings raises the idea that hematopoietic cells including lymphoid cells would possess, in general, intracellular mechanisms to undergo asymmetric cell division.
Authors:
M Sugimoto; T Yasuda
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Thymus     Volume:  5     ISSN:  0165-6090     ISO Abbreviation:  Thymus     Publication Date:  1983 Sep 
Date Detail:
Created Date:  1984-02-14     Completed Date:  1984-02-14     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8009032     Medline TA:  Thymus     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  297-310     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Animals
Cell Differentiation
Cell Division
Chickens
Guinea Pigs
Mice
Rats
T-Lymphocytes / cytology*
Thymus Gland / cytology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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