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Asymmetric cyclopropanation of olefins catalysed by Cu(i) complexes of chiral pyridine-containing macrocyclic ligands ().
MedLine Citation:
PMID:  23202443     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The synthesis and characterisation of copper(i) complexes of chiral pyridine-containing macrocyclic ligands () and their use as catalysts in asymmetric cyclopropanation reactions are reported. All ligands and metal complexes were fully characterised, including crystal structures of some species determined by X-ray diffraction on single crystals. This allowed characterising the very different conformations of the macrocycles which could be induced by different substituents or by metal complexation. The strategy adopted for the ligand synthesis is very flexible allowing several structural modifications. A small library of macrocyclic ligands possessing the same donor properties but with either C(1) or C(2) symmetry was synthesized. Cyclopropane products with both aromatic and aliphatic olefins were obtained in good yields and enantiomeric excesses up to 99%.
Authors:
Brunilde Castano; Stefano Guidone; Emma Gallo; Fabio Ragaini; Nicola Casati; Piero Macchi; Massimo Sisti; Alessandro Caselli
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-3
Journal Detail:
Title:  Dalton transactions (Cambridge, England : 2003)     Volume:  -     ISSN:  1477-9234     ISO Abbreviation:  Dalton Trans     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101176026     Medline TA:  Dalton Trans     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Dipartimento di Chimica, Università di Milano, and ISTM-CNR, Via Golgi 19, 20133 Milano, Italy. alessandro.caselli@unimi.it.
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