Document Detail

Asymmetric cerebral lesion pattern in X-linked adrenoleukodystrophy.
MedLine Citation:
PMID:  16970275     Owner:  NLM     Status:  MEDLINE    
X-linked adrenoleukodystrophy (X-ALD) is an inherited disease caused by peroxisomal dysfunction. X-ALD usually involves the cerebral white matter in an approximately symmetric way. We report a 10-year-old boy with the cerebral form of X-ALD who presented with cognitive impairment and left spastic hemiparesis. Brain magnetic resonance imaging (MRI) showed asymmetric lesions, and the lesions in the right hemisphere were predominant. In the late stage of the disease, bilateral limbs were involved. The cerebral lesions enlarged and appeared approximately symmetric on MRI. The purpose of our report is to highlight asymmetric demyelination in initial presentation of X-ALD.
Shuang Wang; Ji-Min Wu; Yuan-Shen Cheng
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of the Chinese Medical Association : JCMA     Volume:  69     ISSN:  1726-4901     ISO Abbreviation:  J Chin Med Assoc     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-09-14     Completed Date:  2006-10-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101174817     Medline TA:  J Chin Med Assoc     Country:  China (Republic : 1949- )    
Other Details:
Languages:  eng     Pagination:  383-6     Citation Subset:  IM    
Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, China.
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MeSH Terms
Adrenoleukodystrophy / pathology*
Brain / pathology*
Magnetic Resonance Imaging

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