| Asymmetric cell division: recent developments and their implications for tumour biology. | |
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MedLine Citation:
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PMID: 21102610 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The ability of cells to divide asymmetrically is essential for generating diverse cell types during development. The past 10 years have seen tremendous progress in our understanding of this important biological process. We have learned that localized phosphorylation events are responsible for the asymmetric segregation of cell fate determinants in mitosis and that centrosomes and microtubules play important parts in this process. The relevance of asymmetric cell division for stem cell biology has added a new dimension to the field, and exciting connections between asymmetric cell division and tumorigenesis have begun to emerge. |
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Authors:
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Juergen A Knoblich |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Nature reviews. Molecular cell biology Volume: 11 ISSN: 1471-0080 ISO Abbreviation: Nat. Rev. Mol. Cell Biol. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-24 Completed Date: 2010-12-13 Revised Date: 2013-03-14 |
Medline Journal Info:
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Nlm Unique ID: 100962782 Medline TA: Nat Rev Mol Cell Biol Country: England |
Other Details:
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Languages: eng Pagination: 849-60 Citation Subset: IM |
Affiliation:
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Institute of Molecular Biotechnology of Austrian Academy of Science, Doktor Bohr-Gasse 3, 1030 Vienna, Austria. juergen.knoblich@imba.oeaw.ac.at |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Biology / trends* Cell Division / physiology* Cell Polarity / physiology Cell Size Centrosome / physiology Humans Models, Biological Neoplasms / etiology*, pathology Vertebrates / physiology |
| Grant Support | |
ID/Acronym/Agency:
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250342//European Research Council |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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