Document Detail


Asymmetric aminocatalysis--gold rush in organic chemistry.
MedLine Citation:
PMID:  18666089     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Catalysis with chiral secondary amines (asymmetric aminocatalysis) has become a well-established and powerful synthetic tool for the chemo- and enantioselective functionalization of carbonyl compounds. In the last eight years alone, this field has grown at such an extraordinary pace that it is now recognized as an independent area of synthetic chemistry, where the goal is the preparation of any chiral molecule in an efficient, rapid, and stereoselective manner. This has been made possible by the impressive level of scientific competition and high quality research generated in this area. This Review describes this "Asymmetric Aminocatalysis Gold Rush" and charts the milestones in its development. As in all areas of science, progress depends on human effort.
Authors:
Paolo Melchiorre; Mauro Marigo; Armando Carlone; Giuseppe Bartoli
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Angewandte Chemie (International ed. in English)     Volume:  47     ISSN:  1521-3773     ISO Abbreviation:  Angew. Chem. Int. Ed. Engl.     Publication Date:  2008  
Date Detail:
Created Date:  2008-08-04     Completed Date:  2008-09-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370543     Medline TA:  Angew Chem Int Ed Engl     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  6138-71     Citation Subset:  -    
Affiliation:
Department of Organic Chemistry A. Mangini, Alma Mater Studiorum-Università di Bologna, Viale Risorgimento 4, 40136 Bologna, Italy. p.melchiorre@unibo.it
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