Document Detail

Astroglial cells in development, regeneration, and repair.
MedLine Citation:
PMID:  17404377     Owner:  NLM     Status:  MEDLINE    
Three main cellular components have been described in the CNS: neurons, astrocytes, and oligodendrocytes. In the past 10 years, lineage studies first based on retroviruses in the embryonic CNS and then by genetic fate mapping in both the prenatal and postnatal CNS have proposed that astroglial cells can be progenitors for neurons and oligodendrocytes. Hence, the population of astroglial cells is increasingly recognized as heterogeneous and diverse, encompassing cell types performing widely different roles in development and plasticity. Astroglial cells populating the neurogenic niches increase their proliferation after perinatal injury and in young mice can differentiate into neurons and oligodendrocytes that migrate to the cerebral cortex, replacing the cells that are lost. Although much remains to be learned about this process, it appears that the up-regulation of the Fibroblast growth factor receptor is critical for mediating the injury-induced increase in cell division and perhaps for the neuronal differentiation of astroglial cells.
Flora M Vaccarino; Devon M Fagel; Yosif Ganat; Maria E Maragnoli; Laura R Ment; Yasushi Ohkubo; Michael L Schwartz; John Silbereis; Karen M Smith
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry     Volume:  13     ISSN:  1073-8584     ISO Abbreviation:  Neuroscientist     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-03     Completed Date:  2007-05-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9504819     Medline TA:  Neuroscientist     Country:  United States    
Other Details:
Languages:  eng     Pagination:  173-85     Citation Subset:  IM    
Child Study Center, Department of Neurobiology, Yale University Medical School, New Haven, CT, USA.
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MeSH Terms
Astrocytes / cytology,  metabolism*
Cell Differentiation / genetics*
Cell Lineage / genetics*
Cell Proliferation
Central Nervous System / cytology,  growth & development*,  metabolism
Nerve Regeneration / genetics
Neuronal Plasticity / genetics
Receptors, Fibroblast Growth Factor / genetics,  metabolism
Stem Cells / cytology,  metabolism*
Reg. No./Substance:
0/Receptors, Fibroblast Growth Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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