| Astrocytic infection in canine distemper virus-induced demyelination. | |
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MedLine Citation:
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PMID: 2922996 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acute canine distemper virus (CDV)-induced demyelinating lesions were examined with double-labelling immunocytochemistry simultaneously demonstrating CDV antigen and glial fibrillary acidid protein (GFAP) as marker for astrocytes. It was shown that 64% of all astrocytes within the demyelinating lesions were infected and that 95% of all infected cells counted in the lesions were astrocytes. These results suggest that the astrocyte is the main target for CDV and that astroglial infection may play an important role in the mechanism of demyelination. |
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Authors:
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F Mutinelli; M Vandevelde; C Griot; A Richard |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta neuropathologica Volume: 77 ISSN: 0001-6322 ISO Abbreviation: Acta Neuropathol. Publication Date: 1989 |
Date Detail:
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Created Date: 1989-04-18 Completed Date: 1989-04-18 Revised Date: 2007-11-09 |
Medline Journal Info:
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Nlm Unique ID: 0412041 Medline TA: Acta Neuropathol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 333-5 Citation Subset: IM |
Affiliation:
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Institut für Tier-Neurologie, Universität Bern, Switzerland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens, Viral / analysis Astrocytes / immunology, metabolism, microbiology* Demyelinating Diseases / microbiology*, pathology Distemper / microbiology*, pathology Distemper Virus, Canine / immunology Dogs Glial Fibrillary Acidic Protein / metabolism Immunohistochemistry |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Viral; 0/Glial Fibrillary Acidic Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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