Document Detail

Astrocytes and microglia as potential targets for calcitonin gene related peptide in the central nervous system.
MedLine Citation:
PMID:  8846399     Owner:  NLM     Status:  MEDLINE    
Injury of peripheral motoneurons leads to the activation of astrocytes and microglia in the vicinity of the damaged neurons in the central nervous system. It has been proposed that neuropeptides such as the calcitonin gene related peptide (CGRP), which show an increased expression in motoneurons following axotomy, play a role as signalling molecules mediating the interactions between the damaged neurons and surrounding glial cells. Evidence supporting this hypothesis is provided by in vitro investigations of the actions of neuropeptides on glial cells. CGRP induces activation of both astrocytes and microglia at the transcriptional level, as seen by the stimulation of mRNA for the immediate early gene, c-fos, in these cells in culture. In addition to its stimulation of immediate early gene expression, treatment of astrocyte cultures with CGRP stimulated release of the tissue plasminogen activator and led to the accumulation of mRNAs for tissue plasminogen activator and the plasminogen activator inhibitor 1. These components of the plasminogen activator system, which has been implicated in processes of tissue remodelling, are upregulated in astrocytes in the facial nucleus in vivo after facial nerve axotomy. The data suggest a role for CGRP as a mediator of glial cell activation following motoneuron injury.
M Reddington; J Priller; J Treichel; C Haas; G W Kreutzberg
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  73     ISSN:  0008-4212     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1996-10-23     Completed Date:  1996-10-23     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  1047-9     Citation Subset:  IM    
Department of Neuromorphology, Max Planck Institute of Psychiatry, Martinsried, Germany.
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MeSH Terms
Astrocytes / drug effects*,  metabolism
Brain / drug effects
Calcitonin Gene-Related Peptide / pharmacology*
Microglia / drug effects*,  metabolism
Motor Neurons
Plasminogen Activator Inhibitor 1 / biosynthesis
Plasminogen Activators / biosynthesis
Spinal Cord / drug effects
Reg. No./Substance:
0/Plasminogen Activator Inhibitor 1; 83652-28-2/Calcitonin Gene-Related Peptide; EC 3.4.21.-/Plasminogen Activators

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