| Astrocytes in the tempest of multiple sclerosis. | |
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MedLine Citation:
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PMID: 21443873 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Astrocytes are the most abundant cell population within the CNS of mammals. Their glial role is perfectly performed in the healthy CNS as they support functions of neurons. The omnipresence of astrocytes throughout the white and grey matter and their intimate relation with blood vessels of the CNS, as well as numerous immunity-related actions that these cells are capable of, imply that astrocytes should have a prominent role in neuroinflammatory disorders, such as multiple sclerosis (MS). The role of astrocytes in MS is rather ambiguous, as they have the capacity to both stimulate and restrain neuroinflammation and tissue destruction. In this paper we present some of the proved and the proposed functions of astrocytes in neuroinflammation and discuss the effect of MS therapeutics on astrocytes. |
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Authors:
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Djordje Miljković; Gordana Timotijević; Marija Mostarica Stojković |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2011-03-31 |
Journal Detail:
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Title: FEBS letters Volume: 585 ISSN: 1873-3468 ISO Abbreviation: FEBS Lett. Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-11-23 Completed Date: 2012-01-10 Revised Date: 2012-03-22 |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: Netherlands |
Other Details:
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Languages: eng Pagination: 3781-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. |
Affiliation:
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Institute for Biological Research Siniša Stanković, University of Belgrade, Belgrade, Serbia. georgije_zw@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Astrocytes / pathology* Humans Models, Immunological Molecular Targeted Therapy Multiple Sclerosis / pathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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