Document Detail


Astrocytes impose postburst depression of release probability at hippocampal glutamate synapses.
MedLine Citation:
PMID:  20410129     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Many neurons typically fire action potentials in brief, high-frequency bursts with specific consequences for their synaptic output. Here we have examined short-term plasticity engaged during burst activation using electrophysiological recordings in acute rat hippocampal slices. We show that CA3-CA1 glutamate synapses exhibit a prominent depression of presynaptic release probability for approximately 1 s after such a burst. This postburst depression exhibits a distinct cooperativity threshold, is abolished by inhibiting astrocyte metabolism and astrocyte calcium signaling, and is not operational in the developing hippocampus. Our results suggest that astrocytes are actively involved in short-term synaptic depression, shaping synaptic activity during behaviorally relevant neural activity.
Authors:
My Andersson; Eric Hanse
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  30     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-22     Completed Date:  2010-05-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5776-80     Citation Subset:  IM    
Affiliation:
Institute of Neuroscience and Physiology, Gothenburg University, 405 30 G?teborg, Sweden. my.andersson@physiol.gu.se
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MeSH Terms
Descriptor/Qualifier:
Animals
Astrocytes / physiology*
CA1 Region, Hippocampal / physiology*
CA3 Region, Hippocampal / physiology*
Glutamic Acid / physiology*
Hippocampus / physiology
Long-Term Synaptic Depression / physiology*
Neuronal Plasticity / physiology
Probability
Rats
Rats, Wistar
Receptors, Glutamate / physiology
Synapses / physiology*
Chemical
Reg. No./Substance:
0/Receptors, Glutamate; 56-86-0/Glutamic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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