| Astrocytes impose postburst depression of release probability at hippocampal glutamate synapses. | |
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MedLine Citation:
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PMID: 20410129 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Many neurons typically fire action potentials in brief, high-frequency bursts with specific consequences for their synaptic output. Here we have examined short-term plasticity engaged during burst activation using electrophysiological recordings in acute rat hippocampal slices. We show that CA3-CA1 glutamate synapses exhibit a prominent depression of presynaptic release probability for approximately 1 s after such a burst. This postburst depression exhibits a distinct cooperativity threshold, is abolished by inhibiting astrocyte metabolism and astrocyte calcium signaling, and is not operational in the developing hippocampus. Our results suggest that astrocytes are actively involved in short-term synaptic depression, shaping synaptic activity during behaviorally relevant neural activity. |
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Authors:
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My Andersson; Eric Hanse |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 30 ISSN: 1529-2401 ISO Abbreviation: J. Neurosci. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-22 Completed Date: 2010-05-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8102140 Medline TA: J Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 5776-80 Citation Subset: IM |
Affiliation:
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Institute of Neuroscience and Physiology, Gothenburg University, 405 30 G?teborg, Sweden. my.andersson@physiol.gu.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Astrocytes / physiology* CA1 Region, Hippocampal / physiology* CA3 Region, Hippocampal / physiology* Glutamic Acid / physiology* Hippocampus / physiology Long-Term Synaptic Depression / physiology* Neuronal Plasticity / physiology Probability Rats Rats, Wistar Receptors, Glutamate / physiology Synapses / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Glutamate; 56-86-0/Glutamic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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