| Astrocytes and Glioblastoma cells release exosomes carrying mtDNA. | |
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MedLine Citation:
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PMID: 19680595 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cells can exchange information not only by means of chemical and/or electrical signals, but also via microvesicles released into the intercellular space. The present paper, for the first time, provides evidence that Glioblastoma and Astrocyte cells release microvesicles, which carry mitochondrial DNA (mtDNA). These microvesicles have been characterised as exosomes in view of the presence of some protein markers of exosomes, such as Tsg101, CD9 and Alix. Thus, the important finding has been obtained that bonafide exosomes, constitutively released by Glioblastoma cells and Astrocytes, can carry mtDNA, which can be, therefore, transferred between cells. This datum may help the understanding of some diseases due to mitochondrial alterations. |
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Authors:
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Michele Guescini; Susanna Genedani; Vilberto Stocchi; Luigi Francesco Agnati |
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Publication Detail:
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Type: Journal Article Date: 2009-08-13 |
Journal Detail:
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Title: Journal of neural transmission (Vienna, Austria : 1996) Volume: 117 ISSN: 1435-1463 ISO Abbreviation: J Neural Transm Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-07 Completed Date: 2010-03-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9702341 Medline TA: J Neural Transm Country: Austria |
Other Details:
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Languages: eng Pagination: 1-4 Citation Subset: IM |
Affiliation:
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Department of Biomolecular Sciences, University of Urbino 'Carlo Bo', Urbino, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens, CD / metabolism Astrocytes / metabolism* Calcium-Binding Proteins / metabolism Cell Cycle Proteins / metabolism Cell Line, Tumor Cells, Cultured Cerebral Cortex / metabolism DNA, Mitochondrial / metabolism* DNA-Binding Proteins / metabolism Endosomal Sorting Complexes Required for Transport / metabolism Exosomes / metabolism* Gene Dosage Glioblastoma / metabolism* Humans Membrane Glycoproteins / metabolism Rats Transcription Factors / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/CD9 antigen; 0/Calcium-Binding Proteins; 0/Cell Cycle Proteins; 0/DNA, Mitochondrial; 0/DNA-Binding Proteins; 0/Endosomal Sorting Complexes Required for Transport; 0/Membrane Glycoproteins; 0/PDCD6IP protein, human; 0/Pdcd6ip protein, rat; 0/Transcription Factors; 0/Tsg101 protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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