Document Detail

Astrocytes and Glioblastoma cells release exosomes carrying mtDNA.
MedLine Citation:
PMID:  19680595     Owner:  NLM     Status:  MEDLINE    
Cells can exchange information not only by means of chemical and/or electrical signals, but also via microvesicles released into the intercellular space. The present paper, for the first time, provides evidence that Glioblastoma and Astrocyte cells release microvesicles, which carry mitochondrial DNA (mtDNA). These microvesicles have been characterised as exosomes in view of the presence of some protein markers of exosomes, such as Tsg101, CD9 and Alix. Thus, the important finding has been obtained that bonafide exosomes, constitutively released by Glioblastoma cells and Astrocytes, can carry mtDNA, which can be, therefore, transferred between cells. This datum may help the understanding of some diseases due to mitochondrial alterations.
Michele Guescini; Susanna Genedani; Vilberto Stocchi; Luigi Francesco Agnati
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Publication Detail:
Type:  Journal Article     Date:  2009-08-13
Journal Detail:
Title:  Journal of neural transmission (Vienna, Austria : 1996)     Volume:  117     ISSN:  1435-1463     ISO Abbreviation:  J Neural Transm     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-07     Completed Date:  2010-03-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9702341     Medline TA:  J Neural Transm     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  1-4     Citation Subset:  IM    
Department of Biomolecular Sciences, University of Urbino 'Carlo Bo', Urbino, Italy.
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MeSH Terms
Antigens, CD / metabolism
Astrocytes / metabolism*
Calcium-Binding Proteins / metabolism
Cell Cycle Proteins / metabolism
Cell Line, Tumor
Cells, Cultured
Cerebral Cortex / metabolism
DNA, Mitochondrial / metabolism*
DNA-Binding Proteins / metabolism
Endosomal Sorting Complexes Required for Transport / metabolism
Exosomes / metabolism*
Gene Dosage
Glioblastoma / metabolism*
Membrane Glycoproteins / metabolism
Transcription Factors / metabolism
Reg. No./Substance:
0/Antigens, CD; 0/CD9 antigen; 0/Calcium-Binding Proteins; 0/Cell Cycle Proteins; 0/DNA, Mitochondrial; 0/DNA-Binding Proteins; 0/Endosomal Sorting Complexes Required for Transport; 0/Membrane Glycoproteins; 0/PDCD6IP protein, human; 0/Pdcd6ip protein, rat; 0/Transcription Factors; 0/Tsg101 protein

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