| Astragalus membranaceus lectin (AML) induces caspase-dependent apoptosis in human leukemia cells. | |
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MedLine Citation:
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PMID: 22172162 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objectives: Recently, plant lectins have attracted great interest due to their various biological activities such as anti-cancer, anti-fungal and anti-viral activities. We have reported earlier concerning anti-proliferation of human cancer cell lines by a galactose-binding lectin (AML), from a Chinese herb, Astragalus membranaceus. In the present study, detailed investigations into the mechanism of such anti-proliferation properties have been carried out. Materials and methods: Mechanism of apoptosis initiation in K562 cells by AML was investigated by morphology, flow cytometry and western blot analysis. Results: AML induced apoptosis in a caspase-dependent manner in the chronic myeloid leukemia cell line, K562. Furthermore, we observed that cytotoxicity and apoptosis of K562 cells induced by AML were completely abolished in presence of lactose or galactose. Conclusions: Our results suggest that AML could act as a potential anti-cancer drug. |
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Authors:
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L H Huang; Q J Yan; N K Kopparapu; Z Q Jiang; Y Sun |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-16 |
Journal Detail:
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Title: Cell proliferation Volume: - ISSN: 1365-2184 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9105195 Medline TA: Cell Prolif Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 Blackwell Publishing Ltd. |
Affiliation:
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Bioresource Utilization Laboratory, College of Engineering, China Agricultural University, Beijing, China Department of Biotechnology, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China School of Biological Science and Medical Engineering, Beihang University, Beijing, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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