| Astragalosides Rescue Both Cardiac Function and Sarcoplasmic Reticulum Ca(2+) Transport in Rats with Chronic Heart Failure. | |
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MedLine Citation:
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PMID: 21656599 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The study investigated the beneficial effects of astragalosides (AS) on cardiac performance in rats with chronic heart failure. Chronic heart failure was produced by left anterior descending coronary artery ligation, and the therapeutic efficacy of astragalosides at 10, 20 and 40 mg/kg was evaluated. Five weeks after the operation, cardiac function was deficient and sarcoplasmic reticulum Ca(2+) -ATPase (SERCA) activity was significantly reduced. Moreover, SERCA mRNA decreased, while expression of the SERCA down-regulator phospholamban (PLB) was significantly increased. Phosphorylated phospholamban (P-PLB), the form that does not inhibit SERCA, was also reduced by chronic heart failure. Treatment with AS improved left ventricle function and cardiac structure, reversed the depression of SERCA activity, and increased P-PLB. These results suggest that the cardioprotective effect of AS may be due to the increase in P-PLB protein, which disinhibits SERCA activity. Rescue of sarcoplasmic reticulum Ca(2+) cycling by astragalosides could normalize excitation-contraction coupling and improve overall cardiac function. Copyright © 2011 John Wiley & Sons, Ltd. |
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Authors:
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Yi Wang; Yansu Ji; Yongfa Xing; Xiang Li; Xiumei Gao |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-7 |
Journal Detail:
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Title: Phytotherapy research : PTR Volume: - ISSN: 1099-1573 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-6-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8904486 Medline TA: Phytother Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 John Wiley & Sons, Ltd. |
Affiliation:
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TCM Research Center, Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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