Document Detail

Asthma research: the real action is in children.
MedLine Citation:
PMID:  15911455     Owner:  NLM     Status:  MEDLINE    
Many adult diseases have their roots in infancy or even prenatally. If events that initiate these diseases, as opposed to those that propagate the disease state, are to be understood, then the difficult area of how ethically to research problems in infancy must be tackled. Furthermore, the predisposition to archetypally 'pure' adult problems such as chronic obstructive pulmonary disease, may lie antenatally, the effects being masked until the lung starts to age. An additional factor is that the success of paediatricians, for example in ensuring the survival of extremely premature, low birth weight infants leads to adult survivors with potentially a whole new morbidity. The first prerequisite to making progress is a sound understanding of the development of the normal lung and how adverse environmental and genetic influences, such as exposure to environmental tobacco smoke and maternal atopy, respectively, may affect growth. This paper focuses on three key areas: the implications of different pre-school wheezing phenotypes for adult disease; the importance of very early life events in cystic fibrosis; and the long term consequences of chronic lung disease of prematurity. Finally, the ethical principles that must underpin future research in pre-school children is discussed, as well as the means we might use to further our understanding of the relevant early disease processes.
Andrew Bush
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Paediatric respiratory reviews     Volume:  6     ISSN:  1526-0542     ISO Abbreviation:  Paediatr Respir Rev     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-05-24     Completed Date:  2006-01-05     Revised Date:  2009-10-14    
Medline Journal Info:
Nlm Unique ID:  100898941     Medline TA:  Paediatr Respir Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  101-10     Citation Subset:  IM    
Imperial School of Medicine, National Heart and Lung Institute, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK.
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MeSH Terms
Age Factors
Asthma / etiology*
Child, Preschool
Cystic Fibrosis / etiology
Lung / blood supply,  embryology,  growth & development
Lung Diseases / etiology*
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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