| Asthma phenotypes. | |
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MedLine Citation:
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PMID: 19814916 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The many roads leading to the syndrome of asthma have proven to be intricately interconnected. The chronic inflammation of asthma is characterized by airway hyperreactivity and variable reversibility. Past classification systems relied on assessment of daily impairment and the distinction between intrinsic (nonallergic) and extrinsic (allergic). With more precise asthma phenotypes, association studies likely will have greater significance. In addition, patients at higher risk for severe disease can be more effectively managed, and treatments can be directed to responders. In this review, we look at eight identified phenotypes: atopic and nonatopic status, pre-asthma wheezing, inflammatory mediator predominance, aspirin-sensitive, exercise-induced, severe, and flare-prone asthma. Although significant overlap exists among the distinctions, any future phenotype classification system will need to incorporate these eight clinical asthmatic populations. |
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Authors:
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Steve Handoyo; Lanny J Rosenwasser |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current allergy and asthma reports Volume: 9 ISSN: 1534-6315 ISO Abbreviation: Curr Allergy Asthma Rep Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-10-09 Completed Date: 2009-12-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101096440 Medline TA: Curr Allergy Asthma Rep Country: United States |
Other Details:
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Languages: eng Pagination: 439-45 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Allergens
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adverse effects Asthma / classification*, diagnosis, etiology, physiopathology* Humans Inflammation Mediators / physiology Respiratory Sounds / physiopathology Risk Factors Severity of Illness Index |
| Chemical | |
Reg. No./Substance:
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0/Allergens; 0/Inflammation Mediators |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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