Document Detail

Asthma mortality: another opinion--is it a matter of life and ... bread?
MedLine Citation:
PMID:  8096209     Owner:  NLM     Status:  MEDLINE    
There is a general consensus that the mortality rates for asthma in much of the developed world have been increasing for the past 10-15 years. This has occurred despite an improved information base regarding diagnosis and management as well as the development of novel and more effective therapeutic modalities. Several explanations have been proposed for this increase, including a statistical artifact based on a change in the coding criteria for asthma from the International Classification of Diseases Version 8 (ICD-8) to ICD-9, worsened pollution, delays in seeking medical help, behavioral changes, deficits in asthma education of both patients and primary care providers, toxicity of beta agonists, and noncompliance with medications. We suggest that although all of these are potential etiological factors, there may exist still another major etiological risk. There have been dramatic changes in our eating habits and food preparation. In general, we eat less total calories, more meals outside the home, and more refined or prepared foods. With the emphasis on reducing the intake of saturated fats and cholesterol, we eat more polyunsaturated fats both by choice and secondary to manufacturers' attempts to improve the appeal of foods to health-conscious government and the public. The drive to remove animal fats and cholesterol from our diet has resulted in the replacement of animal fats with vegetable oil in food manufacture, fast-food frying, and even home preparation. One result of these dietary habits has been a doubling from 8 to 15% of the percentage of the polyunsaturated linoleic acid in body fat. We postulate that this, and other nutritional changes, will render asthma a more difficult syndrome to manage and will contribute adversely to the inflammatory abnormalities in airways.
C C Chang; S D Phinney; G M Halpern; M E Gershwin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of asthma : official journal of the Association for the Care of Asthma     Volume:  30     ISSN:  0277-0903     ISO Abbreviation:  J Asthma     Publication Date:  1993  
Date Detail:
Created Date:  1993-04-29     Completed Date:  1993-04-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8106454     Medline TA:  J Asthma     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  93-103     Citation Subset:  IM    
Division of Rheumatology/Allergy and Clinical Immunology, University of California, Davis 95616.
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MeSH Terms
Adrenergic beta-Agonists / adverse effects
Air Pollutants / adverse effects
Asthma / epidemiology,  etiology,  mortality*
Diet / adverse effects*
Dietary Fats / adverse effects
Survival Rate
Reg. No./Substance:
0/Adrenergic beta-Agonists; 0/Air Pollutants; 0/Dietary Fats

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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