Document Detail


Asthma as a chronic disease of the innate and adaptive immune systems responding to viruses and allergens.
MedLine Citation:
PMID:  22850884     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Research on the pathogenesis of asthma has traditionally concentrated on environmental stimuli, genetic susceptibilities, adaptive immune responses, and end-organ alterations (particularly in airway mucous cells and smooth muscle) as critical steps leading to disease. The focus of this cascade has been the response to allergic stimuli. An alternative scheme suggests that respiratory viruses and the consequent response of the innate immune system also drives the development of asthma as well as related inflammatory diseases. This conceptual shift raises the possibility that sentinel cells such as airway epithelial cells, DCs, NKT cells, innate lymphoid cells, and macrophages also represent critical components of asthma pathogenesis as well as new targets for therapeutic discovery. A particular challenge will be to understand and balance the innate as well as the adaptive immune responses to defend the host against acute infection as well as chronic inflammatory disease.
Authors:
Michael J Holtzman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-08-01
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  122     ISSN:  1558-8238     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-01     Completed Date:  2012-10-25     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2741-8     Citation Subset:  AIM; IM    
Affiliation:
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO, USA. holtzmanm@wustl.edu
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MeSH Terms
Descriptor/Qualifier:
Adaptive Immunity
Allergens
Animals
Asthma / etiology,  immunology*,  therapy,  virology
Humans
Immunity, Innate
Mice
Models, Immunological
Respiratory Mucosa / immunology,  virology
Respiratory Tract Infections / complications,  immunology
Virus Diseases / complications,  immunology
Grant Support
ID/Acronym/Agency:
U19 AI070489/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Allergens
Comments/Corrections

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