| Asthma, allergy and respiratory infections: the vitamin D hypothesis. | |
| | |
MedLine Citation:
|
PMID: 21933195 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
To cite this article: Bozzetto S, Carraro S, Giordano G, Boner A, Baraldi E. Asthma, allergy, and respiratory infections: the vitamin D hypothesis. Allergy 2011; DOI: 10.1111/j.1398-9995.2011.02711.x. ABSTRACT: The recent discovery that every tissue in the human body has vitamin D receptors and that vitamin D has pleiotropic effects has prompted an increased interest in this hormone. Vitamin D deficiency is widespread and on the increase. There is no consensus on the serum vitamin D levels to consider appropriate for global health, the cutoffs for its deficiency, or the doses to use for its supplementation. Vitamin D seems to correlate closely with host reactions against various respiratory infections. Epidemiological studies have shown that low serum 25-hydroxyvitamin D levels are associated with a higher risk of upper and lower respiratory infections in children and a shortage of vitamin D may contribute to asthmatic patients' symptoms and morbidity rates. There are studies highlighting associations between childhood asthma, fetal lung and/or immune development, and maternal vitamin D intake. An insufficiency of this vitamin also seems to be implicated in the onset of childhood atopy and food allergies. The hypothesis is that vitamin D could have a central role in these pathological situations and that it may represent a novel preventive and/or therapeutic strategy. This article reviews and discusses published data on the relationship between vitamin D and asthma and allergy, emphasizing the need for controlled, prospective studies on vitamin D supplementation to clarify whether it has a role in the prevention of and treatment for asthma and allergic conditions. |
| | |
Authors:
|
S Bozzetto; S Carraro; G Giordano; A Boner; E Baraldi |
Related Documents
:
|
21873895 - Human milk probiotic lactobacillus fermentum cect5716 reduces the incidence of gastroin... 21962285 - Comparison of urine protein profiles in cats without urinary tract disease and cats wit... 6433145 - Complement deficiency states and infection: epidemiology, pathogenesis and consequences... 21894025 - Effect of respiratory syncytial virus infection on plasmacytoid dendritic cell regulati... 17456145 - Application of different methods for the diagnosis of experimental paratuberculosis in ... 2665625 - Toxoplasmic retinochoroiditis--a historical review and current concepts. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-9-21 |
Journal Detail:
|
Title: Allergy Volume: - ISSN: 1398-9995 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
|
Created Date: 2011-9-21 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7804028 Medline TA: Allergy Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2011 John Wiley & Sons A/S. |
Affiliation:
|
Allergy Unit and Respiratory Medicine, Department of Pediatrics, University of Padova, Padova Department of Pediatrics, University Hospital, Verona, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Tyrosine kinase inhibitor sunitinib relieves systemic and oral antigen-induced anaphylaxes in mice.
Next Document: Strategies of a Bornean tropical rainforest water use as a function of rainfall regime: isohydric or...