| Asthma therapy during the first 8 years of life: a PIAMA cohort study. | |
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MedLine Citation:
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PMID: 20170331 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Many studies evaluated asthma medication use in children in a cross-sectional manner, yet little is known about longitudinal use patterns. This study describes the formation of a longitudinal data set on asthma medication use and shows first results regarding the prevalence and incidence of medication use. METHODS: The PIAMA (Prevention and Incidence of Asthma and Mite Allergy) study is a prospective birth cohort study among 3963 Dutch children. Recruitment took place in 1996-1997. The data of the PIAMA birth cohort study were complemented with pharmacy data. Prescription information of family members was used to determine whether medication histories were complete from birth until age 8. The prevalence and incidence of asthma medication use was studied in children for whom complete medication histories were available. RESULTS: A first prescription for asthma medication was filled before age 8 by 280 (36%) children, with 88% starting therapy before age 5. Of all children who started therapy, 91.1% received short-acting beta(2)-agonists and 61.1% inhaled corticosteroids. CONCLUSION: The applied method of data collection rendered a data set including 777 children with complete medication histories for their first 8 years of life. This data set provides the opportunity to study longitudinal medication use patterns. First analyses show that asthma medication is initiated in a rather high percentage of children in this cohort and mainly at an age at which an asthma diagnosis cannot yet be firmly established. |
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Authors:
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Mira G P Zuidgeest; Ellen S Koster; Anke-Hilse Maitland-van der Zee; Henri?tte A Smit; Bert Brunekreef; Hubert G M Leufkens; Gerard H Koppelman; Dirkje S Postma; Johan C de Jongste; Maarten O Hoekstra; |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of asthma : official journal of the Association for the Care of Asthma Volume: 47 ISSN: 1532-4303 ISO Abbreviation: J Asthma Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-22 Completed Date: 2010-04-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8106454 Medline TA: J Asthma Country: England |
Other Details:
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Languages: eng Pagination: 209-13 Citation Subset: IM |
Affiliation:
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Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences (UIPS), Faculty of Science, Utrecht University, 3508 TB Utrecht, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex Hormones
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administration & dosage,
therapeutic use Adrenergic beta-Agonists / administration & dosage, therapeutic use Age of Onset Anti-Asthmatic Agents / administration & dosage, therapeutic use* Asthma / diagnosis, drug therapy*, epidemiology Child Child, Preschool Cholinergic Antagonists / administration & dosage, therapeutic use Drug Prescriptions / statistics & numerical data Dyspnea / epidemiology Female Histamine Antagonists / therapeutic use Humans Infant Kaplan-Meiers Estimate Longitudinal Studies Male Netherlands / epidemiology Respiratory Sounds Sex Factors |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones; 0/Adrenergic beta-Agonists; 0/Anti-Asthmatic Agents; 0/Cholinergic Antagonists; 0/Histamine Antagonists |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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