| Astaxanthin limits exercise-induced skeletal and cardiac muscle damage in mice. | |
| | |
MedLine Citation:
|
PMID: 12626126 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Dietary antioxidants may attenuate oxidative damage from strenuous exercise in various tissues. Beneficial effects of the antioxidant astaxanthin have been demonstrated in vitro, but not yet in vivo. We investigated the effect of dietary supplementation with astaxanthin on oxidative damage induced by strenuous exercise in mouse gastrocnemius and heart. C57BL/6 mice (7 weeks old) were divided into groups: rested control, intense exercise, and exercise with astaxanthin supplementation. After 3 weeks of exercise acclimation, both exercise groups ran on a treadmill at 28 m/min until exhaustion. Exercise-increased 4-hydroxy-2-nonenal-modified protein and 8-hydroxy-2'-deoxyguanosine in gastrocnemius and heart were blunted in the astaxanthin group. Increases in plasma creatine kinase activity, and in myeloperoxidase activity in gastrocnemius and heart, also were lessened by astaxanthin. Astaxanthin showed accumulation in gastrocnemius and heart from the 3 week supplementation. Astaxanthin can attenuate exercise-induced damage in mouse skeletal muscle and heart, including an associated neutrophil infiltration that induces further damage. |
| | |
Authors:
|
Wataru Aoi; Yuji Naito; Kunihiro Sakuma; Masashi Kuchide; Harukuni Tokuda; Takashi Maoka; Shinya Toyokuni; Shigenori Oka; Masahiro Yasuhara; Toshikazu Yoshikawa |
Related Documents
:
|
22805526 - Effects of quercetin supplementation on endurance performance and maximal oxygen consum... 16505076 - Influence of intermittent anaerobic exercise on mouse physical endurance and antioxidan... 12905046 - The effect of reactive oxidant generation in acute exercise-induced proteinuria in trai... 11504656 - The influence of glutathione and cysteine levels on the cytotoxicity of helenanolide ty... 19116436 - The work rate corresponding to ventilatory threshold during steady-state and ramp exerc... 20045396 - Three weeks voluntary running wheel exercise increases endoplasmic reticulum stress in ... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Antioxidants & redox signaling Volume: 5 ISSN: 1523-0864 ISO Abbreviation: Antioxid. Redox Signal. Publication Date: 2003 Feb |
Date Detail:
|
Created Date: 2003-03-10 Completed Date: 2003-11-28 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 100888899 Medline TA: Antioxid Redox Signal Country: United States |
Other Details:
|
Languages: eng Pagination: 139-44 Citation Subset: IM |
Affiliation:
|
Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, 602-0841, Japan. waoi@basic.kpu-m.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adjuvants, Immunologic
/
pharmacology Animals Antioxidants / pharmacology Creatine Kinase / biosynthesis, blood, metabolism Deoxyguanosine / analogs & derivatives*, pharmacology Dietary Supplements Female Immunohistochemistry Mice Mice, Inbred C57BL Muscle, Skeletal / metabolism* Myocardium / metabolism* Oxidative Stress Peroxidase / biosynthesis, blood, metabolism Physical Conditioning, Animal Xanthophylls beta Carotene / analogs & derivatives*, pharmacology* |
| Chemical | |
Reg. No./Substance:
|
0/8-hydroxy-2'-deoxyguanosine; 0/Adjuvants, Immunologic; 0/Antioxidants; 0/Xanthophylls; 472-61-7/astaxanthine; 7235-40-7/beta Carotene; 961-07-9/Deoxyguanosine; EC 1.11.1.7/Peroxidase; EC 2.7.3.2/Creatine Kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Redox control on the cell surface: implications for HIV-1 entry.
Next Document: Anti-vascular endothelial growth factor antibody and nimustine as combined therapy: effects on tumou...