Document Detail

Astaxanthin limits exercise-induced skeletal and cardiac muscle damage in mice.
MedLine Citation:
PMID:  12626126     Owner:  NLM     Status:  MEDLINE    
Dietary antioxidants may attenuate oxidative damage from strenuous exercise in various tissues. Beneficial effects of the antioxidant astaxanthin have been demonstrated in vitro, but not yet in vivo. We investigated the effect of dietary supplementation with astaxanthin on oxidative damage induced by strenuous exercise in mouse gastrocnemius and heart. C57BL/6 mice (7 weeks old) were divided into groups: rested control, intense exercise, and exercise with astaxanthin supplementation. After 3 weeks of exercise acclimation, both exercise groups ran on a treadmill at 28 m/min until exhaustion. Exercise-increased 4-hydroxy-2-nonenal-modified protein and 8-hydroxy-2'-deoxyguanosine in gastrocnemius and heart were blunted in the astaxanthin group. Increases in plasma creatine kinase activity, and in myeloperoxidase activity in gastrocnemius and heart, also were lessened by astaxanthin. Astaxanthin showed accumulation in gastrocnemius and heart from the 3 week supplementation. Astaxanthin can attenuate exercise-induced damage in mouse skeletal muscle and heart, including an associated neutrophil infiltration that induces further damage.
Wataru Aoi; Yuji Naito; Kunihiro Sakuma; Masashi Kuchide; Harukuni Tokuda; Takashi Maoka; Shinya Toyokuni; Shigenori Oka; Masahiro Yasuhara; Toshikazu Yoshikawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Antioxidants & redox signaling     Volume:  5     ISSN:  1523-0864     ISO Abbreviation:  Antioxid. Redox Signal.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-03-10     Completed Date:  2003-11-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100888899     Medline TA:  Antioxid Redox Signal     Country:  United States    
Other Details:
Languages:  eng     Pagination:  139-44     Citation Subset:  IM    
Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, 602-0841, Japan.
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MeSH Terms
Adjuvants, Immunologic / pharmacology
Antioxidants / pharmacology
Creatine Kinase / biosynthesis,  blood,  metabolism
Deoxyguanosine / analogs & derivatives*,  pharmacology
Dietary Supplements
Mice, Inbred C57BL
Muscle, Skeletal / metabolism*
Myocardium / metabolism*
Oxidative Stress
Peroxidase / biosynthesis,  blood,  metabolism
Physical Conditioning, Animal
beta Carotene / analogs & derivatives*,  pharmacology*
Reg. No./Substance:
0/8-hydroxy-2'-deoxyguanosine; 0/Adjuvants, Immunologic; 0/Antioxidants; 0/Xanthophylls; 472-61-7/astaxanthine; 7235-40-7/beta Carotene; 961-07-9/Deoxyguanosine; EC; EC Kinase

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