| Astaxanthin reduces oxidative stress, but not aortic damage in atherosclerotic rabbits. | |
| | |
MedLine Citation:
|
PMID: 19846890 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We evaluated whether carotenoid astaxanthin (ASX) could prevent oxidative and atherosclerotic damage in rabbits. Rabbits received regular chow (control) or an atherogenic diet (1% cholesterol) alone or supplemented with 50, 100, and 500 mg% ASX for 60 days (n = 5-9 per group). The atherogenic diet increased the serum cholesterol levels and the ratio of the intima/media area in the aortic arch. These changes were not prevented by ASX. Atherosclerotic rabbits showed increased aortic lipid peroxidation and nonprotein thiol group (NPSH) levels along with inhibition of glutathione peroxidase (GSH-Px). All ASX doses attenuated lipid peroxidation and the increase in NPSH but not the inhibition of GSH-Px. Aortic superoxide dismutase (SOD), catalase (CAT), and thioredoxin reductase (TrxR) activities were enhanced in atherosclerotic rabbits. Although all ASX doses prevented the increase in SOD activity, only 100 and 500 mg% ASX prevented the increase in CAT activity. Furthermore, these same doses partially prevented the increase in TrxR activity, while 50 mg% ASX completely prevented the effects of the atherogenic diet on this enzyme. However, ASX did not attenuate the hypercholesterolemia or the atherosclerotic lesions caused by the atherogenic diet at any of the doses evaluated. Our results indicate that although ASX did not prevent hypercholesterolemia or atherosclerotic lesions, it could play a beneficial role by preventing lipid peroxidation and changes in antioxidant enzyme activities. |
| | |
Authors:
|
Paula R Augusti; Greicy M M Conterato; Sabrina Somacal; Rocheli Sobieski; Andr??ia Quatrin; Luana Maurer; Marta P Rocha; Ione T Denardin; Tatiana Emanuelli |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-10-21 |
Journal Detail:
|
Title: Journal of cardiovascular pharmacology and therapeutics Volume: 14 ISSN: 1940-4034 ISO Abbreviation: J. Cardiovasc. Pharmacol. Ther. Publication Date: 2009 Dec |
Date Detail:
|
Created Date: 2009-11-11 Completed Date: 2010-01-15 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9602617 Medline TA: J Cardiovasc Pharmacol Ther Country: United States |
Other Details:
|
Languages: eng Pagination: 314-22 Citation Subset: IM |
Affiliation:
|
Department of Biochemistry, Institute of Health Basic Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Aorta / drug effects*, metabolism, pathology* Atherosclerosis / drug therapy* Catalase / metabolism Cholesterol / blood Diet, Atherogenic Dietary Supplements Dose-Response Relationship, Drug Glutathione Peroxidase / antagonists & inhibitors Lipid Peroxidation / drug effects Male Oxidative Stress / drug effects* Rabbits Sulfhydryl Compounds / metabolism Superoxide Dismutase / metabolism Thiobarbituric Acid Reactive Substances / metabolism Thioredoxin-Disulfide Reductase / metabolism Xanthophylls / administration & dosage, pharmacology |
| Chemical | |
Reg. No./Substance:
|
0/Sulfhydryl Compounds; 0/Thiobarbituric Acid Reactive Substances; 0/Xanthophylls; 472-61-7/astaxanthine; 57-88-5/Cholesterol; EC 1.11.1.6/Catalase; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase; EC 1.8.1.9/Thioredoxin-Disulfide Reductase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: International consensus report on the investigation and management of primary immune thrombocytopeni...
Next Document: Contribution of different triggers to the gastric accommodation reflex in humans.