Document Detail


Associations with multiple pituitary hormone deficiency in patients with an ectopic posterior pituitary gland.
MedLine Citation:
PMID:  18331606     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: The presence of an ectopic posterior pituitary gland (EPP) on magnetic resonance imaging (MRI) is associated with hypopituitarism with one or more hormone deficiencies. We aimed to identify risk factors for having multiple pituitary hormone deficiency (MPHD) compared to isolated growth hormone deficiency (IGHD) in patients with an EPP. METHODS: In 67 patients (45 male) with an EPP on MRI, the site (hypothalamic vs. stalk) and surface area (SA) [ x (maximum diameter/2) x (maximum height/2), mm(2)] of the EPP were recorded and compared in patients with IGHD and MPHD in relation to clinical characteristics. RESULTS: In MPHD (n = 32) compared to IGHD (n = 35) patients: age of presentation was younger (1.4 [0.1-10.7]vs. 4.0 [0.1-11.3] years, P = 0.005), major incidents during pregnancy were increased (47%vs. 20%, P = 0.02) as were admissions to a neonatal intensive care unit (NICU) (60%vs. 26%, P = 0.04), whilst EPP SA was lower (12.3 [2.4-34.6]vs. 25.7 [6.9-48.2] mm(2), P < 0.001). In patients with a hypothalamic (n = 56) compared to a stalk sited EPP (n = 11): prevalence of MPHD was greater (55%vs. 9%,P = 0.05) and EPP surface area was smaller (17.3 [2.4-48.2]vs. 25.3 [11.8-38.5] mm(2), P < 0.001). In regression analysis, after adjusting for age, presence of MPHD was associated with: major incidents during pregnancy (RR 6.8 [95%CI 1.2-37.7]), hypothalamic EPP site (RR 10.9 [1.0-123.9]) and small EPP SA (RR 2.5 [1.0-5.0] for tertiles of SA). CONCLUSION: In patients with an EPP, adverse antenatal events, size (small) and position (hypothalamic) of the posterior pituitary gland on MRI were associated with MPHD. These findings suggest that adverse factors during pregnancy may be important for the development of an EPP.
Authors:
P G Murray; C Hague; O Fafoula; L Patel; A L Raabe; C Cusick; C M Hall; N B Wright; R Amin; P E Clayton
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2008-03-10
Journal Detail:
Title:  Clinical endocrinology     Volume:  69     ISSN:  1365-2265     ISO Abbreviation:  Clin. Endocrinol. (Oxf)     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-29     Completed Date:  2009-08-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  England    
Other Details:
Languages:  eng     Pagination:  597-602     Citation Subset:  IM    
Affiliation:
Departments of Paediatric Endocrinology, Royal Manchester Children's Hospital, Manchester, UK. peter.clayton@manchester.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Child
Child, Preschool
Choristoma / complications,  epidemiology*
Cohort Studies
Female
Follow-Up Studies
Humans
Hypopituitarism / complications,  epidemiology*
Hypothalamic Diseases / complications,  epidemiology*
Infant
Infant, Newborn
Male
Pituitary Gland, Posterior*
Pituitary Hormones / deficiency*
Pregnancy
Prevalence
Chemical
Reg. No./Substance:
0/Pituitary Hormones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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