Document Detail


Associations of tibia lead, DMSA-chelatable lead, and blood lead with measures of peripheral nervous system function in former organolead manufacturing workers.
MedLine Citation:
PMID:  11241558     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The goals of the present study were to compare and contrast associations of blood lead, DMSA-chelatable lead, current tibia lead, and back-extrapolated "peak" tibia lead with four peripheral nervous system (PNS) sensory and motor function measures in older males with past exposure to organic and inorganic lead. METHODS: Data were collected from former organolead manufacturing workers with an average of 16 years since last occupational lead exposure. Current tibia lead levels were measured by (109)Cd x-ray fluorescence. Sensory pressure thresholds (index and pinky fingers) and pinch and grip strength were measured with the Pressure-Specified Sensory Device (PSSD). RESULTS: In adjusted analyses, none of the four lead biomarkers was associated with sensory pressure threshold of the index finger or pinch or grip strength. In contrast, all four biomarkers were associated (P < or = 0.10) with pressure threshold of the pinky finger. The final linear regression models accounted for a small proportion of the variance in the sensory (1-3%) and motor measures (10-21%). CONCLUSIONS: This study found no strong association between lead biomarkers and selected PNS sensory or motor function measures among former organolead manufacturing workers with no recent occupational exposure to lead. Previously reported CNS findings in this cohort suggest that the PNS may be less sensitive to the chronic toxic effects of lead in this dose range among adults. It is also possible that the PNS has a greater capacity for repair than does the CNS, or that the PNS measures were less sensitive for detection of lead-related health outcomes than were the CNS measures.
Authors:
P L Tassler; B S Schwartz; J Coresh; W F Stewart; A C Todd
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of industrial medicine     Volume:  39     ISSN:  0271-3586     ISO Abbreviation:  Am. J. Ind. Med.     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-03-12     Completed Date:  2001-05-31     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8101110     Medline TA:  Am J Ind Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  254-61     Citation Subset:  IM    
Copyright Information:
Copyright 2001 Wiley-Liss, Inc.
Affiliation:
Department of Epidemiology, Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland 21205, USA. bschwart@jhsph.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Chemical Industry / manpower*
Cohort Studies
Hand Strength / physiology
Humans
Lead / analysis*
Male
Middle Aged
Motor Activity / physiology
Peripheral Nervous System / physiopathology*
Sensory Thresholds / physiology
Succimer / diagnostic use*
Tibia / radiography*
Touch
Grant Support
ID/Acronym/Agency:
R01 AG10785/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
304-55-2/Succimer; 7439-92-1/Lead

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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