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Associations of serum 25-hydroxyvitamin D with circulating PTH, phosphate and calcium in patients with primary hyperparathyroidism.
MedLine Citation:
PMID:  23036072     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Despite NIH clinical recommendations, many clinicians are reluctant to replace vitamin D in hypercalcaemic patients with primary hyperparathyroidism (PHP) due to concerns over aggravating hypercalcaemia. Furthermore the optimum level of vitamin D replacement in PHP remains unclear. METHODS: We performed a large retrospective study in order to determine whether a relationship exists between serum 25-hydroxyvitamin D levels, calcium and other important biochemical markers in patients with PHP. Serum, plasma and urinary biochemical measurements were collected from 251 hypercalcaemic patients diagnosed with PHP. RESULTS: When examining overall mean circulating levels during clinical follow-up, serum 25-hydroxyvitamin D correlated highly significantly with plasma PTH (r = -0.23, P = 0.0003) and serum phosphate (r = 0.16, P = 0.0119). No significant relationship was observed between serum calcium and 25-hydroxyvitamin D (r = 0.002, P = 0.98). Mean plasma PTH during clinical follow-up was 51% lower in patients with serum 25-hydroxyvitamin D > 60nmol/L when compared with patients who had 25-hydroxyvitamin D < 20nmol/L (P < 0.01). CONCLUSIONS: Patients with PHP who have 25-hydroxyvitamin D levels > 60 nmol/L have significantly reduced PTH hypersecretion when compared with patients with deficient vitamin D levels, without exhibiting worse hypercalcaemia. © 2012 Blackwell Publishing Ltd.
Authors:
Channa N Jayasena; Manish Modi; Fausto Palazzo; Akila De Silva; Mandy Donaldson; Karim Meeran; Waljit S Dhillo
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-5
Journal Detail:
Title:  Clinical endocrinology     Volume:  -     ISSN:  1365-2265     ISO Abbreviation:  Clin. Endocrinol. (Oxf)     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Blackwell Publishing Ltd.
Affiliation:
Section of Investigative Medicine, Imperial College London, Hammersmith Hospital, London, UK.
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