| Associations of serum 25-hydroxyvitamin D with circulating PTH, phosphate and calcium in patients with primary hyperparathyroidism. | |
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MedLine Citation:
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PMID: 23036072 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Despite NIH clinical recommendations, many clinicians are reluctant to replace vitamin D in hypercalcaemic patients with primary hyperparathyroidism (PHP) due to concerns over aggravating hypercalcaemia. Furthermore the optimum level of vitamin D replacement in PHP remains unclear. METHODS: We performed a large retrospective study in order to determine whether a relationship exists between serum 25-hydroxyvitamin D levels, calcium and other important biochemical markers in patients with PHP. Serum, plasma and urinary biochemical measurements were collected from 251 hypercalcaemic patients diagnosed with PHP. RESULTS: When examining overall mean circulating levels during clinical follow-up, serum 25-hydroxyvitamin D correlated highly significantly with plasma PTH (r = -0.23, P = 0.0003) and serum phosphate (r = 0.16, P = 0.0119). No significant relationship was observed between serum calcium and 25-hydroxyvitamin D (r = 0.002, P = 0.98). Mean plasma PTH during clinical follow-up was 51% lower in patients with serum 25-hydroxyvitamin D > 60nmol/L when compared with patients who had 25-hydroxyvitamin D < 20nmol/L (P < 0.01). CONCLUSIONS: Patients with PHP who have 25-hydroxyvitamin D levels > 60 nmol/L have significantly reduced PTH hypersecretion when compared with patients with deficient vitamin D levels, without exhibiting worse hypercalcaemia. © 2012 Blackwell Publishing Ltd. |
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Authors:
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Channa N Jayasena; Manish Modi; Fausto Palazzo; Akila De Silva; Mandy Donaldson; Karim Meeran; Waljit S Dhillo |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-5 |
Journal Detail:
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Title: Clinical endocrinology Volume: - ISSN: 1365-2265 ISO Abbreviation: Clin. Endocrinol. (Oxf) Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0346653 Medline TA: Clin Endocrinol (Oxf) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 Blackwell Publishing Ltd. |
Affiliation:
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Section of Investigative Medicine, Imperial College London, Hammersmith Hospital, London, UK. |
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