Document Detail


Associations of pregnancy characteristics with maternal and cord steroid hormones, angiogenic factors, and insulin-like growth factor axis.
MedLine Citation:
PMID:  21947778     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The objective of this study was to comprehensively profile biological factors in pregnancy that have been postulated to be important components of the in utero environment and may also have relevance to later susceptibility to cancer and other chronic diseases.
METHODS: Steroid sex hormones, IGFs, and angiogenic factors were measured in maternal and cord serum from term normotensive pregnancies. Spearman correlations and linear regression estimated relationships among the biological factors and clinical characteristics.
RESULTS: The analytes were generally not correlated between maternal and fetal circulations. However, significant correlations were demonstrated among several analytes within maternal or cord samples. A few analytes were associated with clinical characteristics (e.g., maternal IGF-1 and IGFBP-3 were inversely correlated with offspring birth weight, while maternal leptin and cord testosterone were positively correlated with this characteristic). Maternal androgens were higher in African-Americans than whites, and maternal PlGF and soluble fms-like tyrosine kinase-1 (sFlt-1) were higher in male than female offspring.
CONCLUSIONS: There were significant correlations among analytes, but the patterns differed depending on whether they were measured in the maternal or fetal circulation. The number and magnitude of correlations among analytes, however, should affect the design and interpretation of future studies.
Authors:
Jessica M Faupel-Badger; Yuping Wang; S Ananth Karumanchi; Frank Stanczyk; Michael Pollak; Thomas McElrath; Robert N Hoover; Rebecca Troisi
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-09-24
Journal Detail:
Title:  Cancer causes & control : CCC     Volume:  22     ISSN:  1573-7225     ISO Abbreviation:  Cancer Causes Control     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-10-17     Completed Date:  2012-04-12     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  9100846     Medline TA:  Cancer Causes Control     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1587-95     Citation Subset:  IM    
Affiliation:
Cancer Prevention Fellowship Program, Center for Cancer Training, National Cancer Institute, 6120 Executive Blvd. (EPS), Bethesda, MD 20892-7105, USA. badgerje@mail.nih.gov
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MeSH Terms
Descriptor/Qualifier:
Adult
Angiogenesis Inducing Agents / blood,  metabolism*
Female
Fetal Blood / metabolism
Gonadal Steroid Hormones / blood,  metabolism*
Humans
Insulin-Like Growth Factor II / metabolism*
Leptin / blood,  metabolism*
Male
Pregnancy
Pregnancy Complications / blood,  metabolism*
Young Adult
Grant Support
ID/Acronym/Agency:
Z99 CA999999/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Angiogenesis Inducing Agents; 0/Gonadal Steroid Hormones; 0/Leptin; 67763-97-7/Insulin-Like Growth Factor II
Comments/Corrections

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