Document Detail

Associations of postnatal growth with asthma and atopy: the PROBIT Study.
MedLine Citation:
PMID:  23374010     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: It has been hypothesised that postnatal weight and length/height gain are variously related to wheeze, asthma and atopy; however, supporting evidence is limited and inconsistent.
METHODS: Weights and lengths/heights of 12,171 term infants were measured from birth to 12 months and at 6.5 yr and extracted from polyclinic records prospectively obtained between 12 and 60 months. Atopic phenotypes were ascertained at 6.5 yr with the International Study of Asthma and Allergy in Childhood questionnaire and skin prick tests. Logistic regression models investigated whether rates of weight and length/height gain from infancy to mid-childhood were associated with atopy phenotypes that have occurred ever or in the last 12 months.
RESULTS: After controlling for confounders and prior weight and length/height gain, all weight gain variables except birth weight were positively associated with ever having wheezed (p < 0.1). A one s.d. increase in weight gain rate between 0 and 3 months was associated with a 12% increase (2-23%) in allergic rhinitis ever. No other consistent patterns of association were found for weight gain or length/height gain rate between 0 and 60 months with atopic outcomes at 6.5 yr. In contrast, all atopy outcomes except for ever having asthma were associated with current weight and height, even after controlling for prior growth.
CONCLUSION: Current height and weight are more strongly associated with the development of atopic phenotypes in childhood than patterns of infant and early childhood growth, which may well reflect reverse causality (atopy effects on growth) or residual confounding by an unknown common cause of growth and atopy.
Emma L Anderson; Abigail Fraser; Richard M Martin; Michael S Kramer; Emily Oken; Rita Patel; Kate Tilling;
Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-02-03
Journal Detail:
Title:  Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology     Volume:  24     ISSN:  1399-3038     ISO Abbreviation:  Pediatr Allergy Immunol     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-19     Completed Date:  2013-09-09     Revised Date:  2014-03-06    
Medline Journal Info:
Nlm Unique ID:  9106718     Medline TA:  Pediatr Allergy Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  122-30     Citation Subset:  IM    
Copyright Information:
© 2013 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd.
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MeSH Terms
Age Factors
Asthma / diagnosis,  etiology*,  physiopathology
Birth Weight
Body Height*
Chi-Square Distribution
Confounding Factors (Epidemiology)
Hypersensitivity, Immediate / diagnosis,  etiology*,  physiopathology
Infant, Newborn
Intradermal Tests
Logistic Models
Multivariate Analysis
Odds Ratio
Predictive Value of Tests
Prospective Studies
Republic of Belarus
Risk Factors
Weight Gain*
Grant Support
0701594//Medical Research Council; G0600705//Medical Research Council; G0701594//Medical Research Council; K24 HD069408/HD/NICHD NIH HHS; MOP 53155//Canadian Institutes of Health Research; R01 HD 050758/HD/NICHD NIH HHS; R01 HD050758/HD/NICHD NIH HHS
Natalia Bazulko / ; Olga Gritsenko / ; Lidia Ovchinikova / ; Julia Rizkovskaya / ; Natalia Andreeva / ; Tatiana Avdeichuk / ; Elena Avsiuk / ; Irina Baikevich / ; Zinaida Bisucova / ; Irina Bujko / ; Tamara Galushkina / ; Marina Gotovchi / ; Danuta Iodkovskaya / ; Larisa Kebikova / ; Galina Kluchnikova / ; Maria Kotliarovich / ; Galina Kovalevskaya / ; Natalia Krokas / ; Nadezda Kushkova / ; Afanasia Lazarenko / ; Ludmila Lazuta / ; Zinaida Liamkina / ; Raisa Lisiura / ; Tamara Nabedo / ; Svetlana Pleskach / ; Oksana Potapenko / ; Svetlana Pridhodoskaya / ; Valentina Rahotskaya / ; Irina Rogach / ; Ludmila Rutkovskaya / ; Natalia Senchuk / ; Elena Seraia / ; Ludmila Sheveleva / ; Vera Shota / ; Anna Silvanovich / ; Lilia Smolskaya / ; Valentina Solovey / ; Zoya Solovyova / ; Natalia Tsarik / ; Nadezda Turkovskaya / ; Oxana Zarodova /

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