Document Detail

Associations of plasma C-reactive protein levels with the presence and extent of coronary stenosis in patients with stable coronary artery disease.
MedLine Citation:
PMID:  15585215     Owner:  NLM     Status:  MEDLINE    
Prospective studies showed plasma high sensitivity C-reactive protein (hsCRP) levels to be a powerful predictor of cardiac events. However, the association between hsCRP levels and the extent of coronary stenosis in patients with coronary artery disease (CAD) remains controversial. We investigated the association between hsCRP levels and the extent of coronary stenosis in 273 patients undergoing elective coronary angiography. Plasma hsCRP levels were higher in patients with CAD than in those without CAD (0.70 mg/l versus 0.56 mg/l, P < 0.02), but hsCRP levels did not correlate with the number of >50% stenotic vessels and were not a significant factor for CAD. However, after the exclusion of 76 patients taking statins, a step-wise increase in hsCRP levels was found depending on the number of >50% stenotic vessels: 0.50 in CAD(-), 0.68 in 1-vessel, 0.77 in 2-vessel, and 0.88 mg/l in 3-vessel disease (P < 0.01). The hsCRP levels also correlated with the numbers of >50% and >25% stenotic segments (r = 0.30 and 0.32, P < 0.001). Multivariate analysis revealed the hsCRP levels to be a significant factor for CAD. Thus, after the exclusion of patients with statins, plasma hsCRP levels were found to be associated with the presence and extent of coronary stenosis in patients with stable CAD.
Hiroaki Taniguchi; Yukihiko Momiyama; Reiko Ohmori; Atsushi Yonemura; Takeshi Yamashita; Seiichi Tamai; Haruo Nakamura; Fumitaka Ohsuzu
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Atherosclerosis     Volume:  178     ISSN:  0021-9150     ISO Abbreviation:  Atherosclerosis     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2004-12-08     Completed Date:  2005-04-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  173-7     Citation Subset:  IM    
First Department of Internal Medicine, National Defense Medical College, Saitama, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan.
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MeSH Terms
C-Reactive Protein / metabolism*
Coronary Angiography*
Coronary Artery Disease / blood*,  drug therapy,  radiography*
Coronary Stenosis / blood*,  drug therapy,  radiography*
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
Middle Aged
Reg. No./Substance:
0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 9007-41-4/C-Reactive Protein

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