| Associations of obesity with triglycerides and C-reactive protein are attenuated in adults with high red blood cell eicosapentaenoic and docosahexaenoic acids. | |
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MedLine Citation:
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PMID: 21427737 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: N-3 fatty acids are associated with favorable, and obesity with unfavorable, concentrations of chronic disease risk biomarkers. OBJECTIVE: We examined whether high eicosapentaenoic (EPA) and docosahexaenoic (DHA) acid intakes, measured as percentages of total red blood cell (RBC) fatty acids, modify associations of obesity with chronic disease risk biomarkers. METHODS: In a cross-sectional study of 330 Yup'ik Eskimos, generalized additive models (GAM) and linear and quadratic regression models were used to examine associations of BMI with biomarkers across RBC EPA and DHA categories. RESULTS: Median (5th-95th percentile) RBC EPA and DHA were 2.6% (0.5-5.9%) and 7.3% (3.3-8.9%), respectively. In regression models, associations of BMI with triglycerides, glucose, insulin, C-reactive protein (CRP) and leptin differed significantly by RBC EPA and DHA. The GAM confirmed regression results for triglycerides and CRP: at low RBC EPA and RBC DHA, the predicted increases in triglycerides and CRP concentrations associated with a BMI increase from 25 to 35 were 99.5±45.3 mg/dl (106%) and 137.8±71.0 mg/dl (156%), respectively, for triglycerides and 1.2±0.7 mg/l (61%) and 0.8±1.0 mg/l (35%), respectively, for CRP. At high RBC EPA and RBC DHA, these predicted increases were 13.9±8.1 mg/dl (23%) and 12.0±12.3 mg/dl (18%), respectively, for triglycerides and 0.5±0.5 mg/l (50%) and -0.5±0.6 mg/l (-34%), respectively, for CRP. CONCLUSIONS: In this population, high RBC EPA and DHA were associated with attenuated dyslipidemia and low-grade systemic inflammation among overweight and obese persons. This may help inform recommendations for n-3 fatty acid intakes in the reduction of obesity-related disease risk. |
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Authors:
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Z Makhoul; A R Kristal; R Gulati; B Luick; A Bersamin; D O'Brien; S E Hopkins; C B Stephensen; K L Stanhope; P J Havel; B Boyer |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-03-23 |
Journal Detail:
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Title: European journal of clinical nutrition Volume: 65 ISSN: 1476-5640 ISO Abbreviation: Eur J Clin Nutr Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-07-06 Completed Date: 2011-11-09 Revised Date: 2012-01-04 |
Medline Journal Info:
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Nlm Unique ID: 8804070 Medline TA: Eur J Clin Nutr Country: England |
Other Details:
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Languages: eng Pagination: 808-17 Citation Subset: IM |
Affiliation:
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Cancer Prevention Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA. zmakhoul@fhcrc.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Alaska / epidemiology Biological Markers / blood Body Mass Index C-Reactive Protein / analysis* Cross-Sectional Studies Docosahexaenoic Acids / blood Dyslipidemias / epidemiology, etiology*, prevention & control Eicosapentaenoic Acid / blood Erythrocytes / metabolism* Fatty Acids, Omega-3 / blood* Female Humans Inuits Male Middle Aged Models, Statistical Obesity / blood, immunology*, physiopathology* Overweight / blood, immunology, physiopathology Risk Factors Triglycerides / blood* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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P20 RR016430/RR/NCRR NIH HHS; P20 RR016430-08/RR/NCRR NIH HHS; R01 DK074842/DK/NIDDK NIH HHS; R01 DK074842-02/DK/NIDDK NIH HHS; R01 DK074842-05/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Fatty Acids, Omega-3; 0/Triglycerides; 1553-41-9/Eicosapentaenoic Acid; 25167-62-8/Docosahexaenoic Acids; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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